328284-59-9Relevant articles and documents
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1
Kortum, Steven W.,Benson, Timothy E.,Bienkowski, Michael J.,Emmons, Thomas L.,Prince, D. Bryan,Paddock, Donna J.,Tomasselli, Alfredo G.,Moon, Joseph B.,LaBorde, Alice,TenBrink, Ruth E.
, p. 3378 - 3383 (2008/02/09)
The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
