328402-46-6

Basic information

• Product Name: Benzoic acid, 2,4-dichloro-5-fluoro-, hydrazide
• CAS NO: 328402-46-6
• Molecular Formula: C7H5Cl2FN2O
• Molecular Weight: 223.034
• Mol File: 328402-46-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2,4-dichloro-5-fluoro-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2,4-dichloro-5-fluoro-, hydrazide(328402-46-6)
• EPA Substance Registry System: Benzoic acid, 2,4-dichloro-5-fluoro-, hydrazide(328402-46-6)

Safety Data

• Hazardous Substances Data: 328402-46-6(Hazardous Substances Data)

Upstream product

• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 
• 103318-75-8 2,4-Dichloro-5-fluorobenzoic acid ethyl ester 

Downstream Products

• 675574-52-4 2,6-difluoro-benzoic acid N'-(2,4-dichloro-5-fluoro-benzoyl)-hydrazide 
• 497182-11-3 5-(2,4-dichloro-5-fluorophenyl)-2-(chloromethyl)-1,3,4-oxadiazole 
• 849132-72-5 5-(2,4-dichloro-5-fluoro-phenyl)-[1,3,4]oxadiazole-2-thiol 

Relevant articles and documents

Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles

A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic

Synthesis of some new fluorine containing 1,3,4-oxadiazole derivatives as potential antibacterial and anticancer agents

The synthesis of a number of 1,3,4-oxadiazole derivatives have been described. 2,4-Dichloro-5-fluorobenzoyl hydrazine 1 on reacting with aromatic acids in presence of phosphorus oxychloride affords 2,5-disubstituted-1,3,4- oxadiazoles 2a-j. Aroyl hydrazine on reacting with carbon disulphide under basic condition gives oxadiazol-2-thione 3. Oxadiazol-2-thiones are regioselectively aminomethylated to give N-aminomethylated products 4a-c. Further, 3 undergoes regioselective alkylation on treating with alkyl/aroyl halides to give S-alkyl/aroyl products 5a-c. All the newly synthesized compounds have been screened for their antibacterial activity. Most of them show promising antibacterial activity. Also two out of nine compounds show anticancer activity in the primary anticancer assay.

Synthesis and antifeedant activity of new oxadiazolyl 3(2H)-pyridazinones

A total of 20 new compounds containing the oxadiazolyl 3(2H)-pyridazinone moiety were synthesized. The structures of all the compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. Their insect antifeedant activities against Asiatic corn borer Ostrinia furnacalis (Guenee) were examined and compared with commercial azadirachtin. The compounds exhibited significant levels of activity. The feeding deterrency values of IIIa,j were 57% and 51% at 500 mg/kg concentration, respectively.