32857-48-0

Basic information

• Product Name: N-(4-bromophenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-bromophenyl)-4-methylbenzenesulfonamide
• CAS NO: 32857-48-0
• Molecular Formula: C₁₃H₁₂BrNO₂S
• Molecular Weight: 326.20888
• Mol File: 32857-48-0.mol
• Article Data: 50

Chemical Properties

• Boiling Point: 431.5 °C at 760 mmHg
• Flash Point: 214.8 °C
• Appearance: /
• Density: 1.545 g/cm³
• Vapor Pressure: 1.19E-07mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: N-(4-bromophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromophenyl)-4-methylbenzenesulfonamide(32857-48-0)
• EPA Substance Registry System: N-(4-bromophenyl)-4-methylbenzenesulfonamide(32857-48-0)

Safety Data

• Hazardous Substances Data: 32857-48-0(Hazardous Substances Data)

Usage

General Description

N-(4-bromophenyl)-4-methylbenzenesulfonamide is a chemical compound with the molecular formula C13H13BrNO2S. It is a sulfonamide derivative, containing a 4-bromophenyl group and a 4-methylbenzenesulfonamide group. N-(4-bromophenyl)-4-methylbenzenesulfonamide is commonly used in pharmaceutical research and development, particularly in the synthesis of potential drug candidates and as an intermediate in the production of pharmaceuticals. It exhibits potential biological activities and is being studied for its potential therapeutic applications in various fields such as anti-inflammatory, antimicrobial, and antitumor activities. Due to its structural and pharmacological properties, N-(4-bromophenyl)-4-methylbenzenesulfonamide is an important compound in medicinal chemistry and drug discovery.

InChI:InChI=1/C13H12BrNO2S/c1-10-2-8-13(9-3-10)18(16,17)15-12-6-4-11(14)5-7-12/h2-9,15H,1H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 106-40-1 4-bromo-aniline 
• 68-34-8 phenyl toluenesulfonamide 
• 589-87-7 1,4-bromoiodobenzene 
• 70-55-3 toluene-4-sulfonamide 
• 5467-74-3 4-Bromophenylboronic acid 
• 941-55-9 4-toluenesulfonyl azide 
• 104-15-4 toluene-4-sulfonic acid 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 21849-40-1 dibromamine-T 
• 586-78-7 para-nitrophenyl bromide 
• 3623-23-2 4-bromonitrosobenzene 
• 106-49-0 p-toluidine 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 121234-35-3 1,5-bis-[4-bromo-N-(toluene-4-sulfonyl)-anilino]-pentane 
• 875827-47-7 N-(4-bromo-phenyl)-N-(toluene-4-sulfonyl)-β-alanine 
• 119572-27-9 oxalic acid bis-[4-bromo-N-(toluene-4-sulfonyl)-anilide] 
• 104-15-4 toluene-4-sulfonic acid 
• 121086-19-9 (4-bromophenyl)isopropylamine 
• 32857-49-1 N-(4-bromophenyl)-N,4-dimethylbenzenesulfonamide 
• 5332-25-2 6-bromoquinoline 
• 333383-90-7 6-bromo-1-(toluene-4-sulfonyl)-1,2-dihydro-quinoline 
• 53973-85-6 N-Methyl-2-(4-methylphenylsulfonyl)benzolamin 
• 16879-68-8 4-benzoesaeure 
• 95793-81-0 5-Methyl-2-benzoesaeure 
• 101580-46-5 N,N'-bis-(4-bromo-phenyl)-pentanediyldiamine 
• 1133046-88-4 N-(2-(4-methoxyphenyl)-2,3-dihydrobenzofuran-5-yl)-4-methylbenzenesulfonamide 
• 1207865-28-8 C₁₉H₂₄BrNO₃S 

Relevant articles and documents

Ligand-Controlled Regiodivergence for Catalytic Stereoselective Semireduction of Allenamides

Ligand-controlled regiodivergence has been developed for catalytic semireduction of allenamides with excellent chemo- and stereocontrol. This system also provides an example of catalytic regiodivergent semireduction of allenes for the first time. The divergence of the semireduction is enabled by ligand switch with the same palladium pre-catalyst under operationally simple and mild conditions. Monodentate ligand XPhos exclusively promotes selective 1,2-semireduction to afford allylic amides, while bidentate ligand BINAP completely switched the regioselectivity to 2,3-semireduction, producing (E)-enamide derivatives.

Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.

KCC-1 aminopropyl-functionalized supported on iron oxide magnetic nanoparticles as a novel magnetic nanocatalyst for the green and efficient synthesis of sulfonamide derivatives

A new magnetic nanocatalyst (Fe3O4@KCC-1-npr-NH2) was synthesized directly through the reaction of Fe3O4@KCC-1 with (3-aminopropyl) triethoxysilane (APTES) using a hydrothermal protocol. Prepared nanocomposite was used as a magnetically reusable nanocatalyst for an efficient synthesis of a broad range of sulfonamide derivatives in water as a green solvent at room temperature and the products are collected by filtration with excellent yields (85–97%). The nanocatalyst could be remarkably recovered and reused after ten times without any significant decrease in activity. This mild and simple synthesis method offers some advantages including short reaction time, high yield and simple work-up procedure.