3286-88-2

Basic information

• Product Name: Methanone, (4-bromophenyl)(2,4-dihydroxyphenyl)-
• Synonyms: 4'-Brom-2,4-dihydroxy-benzophenon;(4-bromo-phenyl)-(2,4-dihydroxyphenyl)-methanone;4'-bromo-2,4-dihydroxy-benzophenone;(4-Bromo-phenyl)-(2,4-dihydroxy-phenyl)-methanone
• CAS NO: 3286-88-2
• Molecular Formula: C13H9BrO3
• Molecular Weight: 293.11300
• Mol File: 3286-88-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 169 °C
• CAS DataBase Reference: Methanone, (4-bromophenyl)(2,4-dihydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-bromophenyl)(2,4-dihydroxyphenyl)-(3286-88-2)
• EPA Substance Registry System: Methanone, (4-bromophenyl)(2,4-dihydroxyphenyl)-(3286-88-2)

Safety Data

• Hazardous Substances Data: 3286-88-2(Hazardous Substances Data)

Usage

Preparation

preparation by reaction of p-bromobenzo_nitrile with resorcinol in the presence of zinc chloride and hydrochloric acid in ethyl ether in an ice bath for 1 or 2 days, followed by hydrolysis of the ketimine hydrochloride so formed with boiling water.

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 586-75-4 4-chlorobenzoyl chloride 
• 500293-60-7 (4-bromophenyl)(2,4-dimethoxyphenyl)methanone 

Downstream Products

• 192443-32-6 3-(4-bromophenyl)benzo[d]isoxazol-6-ol 
• 579816-09-4 6-(6-bromohexyloxy)-3-(4-bromophenyl)benzo[d]isoxazole 

Relevant articles and documents

The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa

Natural products represent a rich source of antibiotics that address versatile cellular targets. The deconvolution of their targets via chemical proteomics is often challenged by the introduction of large photocrosslinkers. Here we applied elegaphenone, a largely uncharacterized natural product antibiotic bearing a native benzophenone core scaffold, for affinity-based protein profiling (AfBPP) in Gram-positive and Gram-negative bacteria. This study utilizes the alkynylated natural product scaffold as a probe to uncover intriguing biological interactions with the transcriptional regulator AlgP. Furthermore, proteome profiling of a Pseudomonas aeruginosa AlgP transposon mutant provided unique insights into the mode of action. Elegaphenone enhanced the elimination of intracellular P. aeruginosa in macrophages exposed to sub-inhibitory concentrations of the fluoroquinolone antibiotic norfloxacin.