32863-01-7

Basic information

• Product Name: 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE
• Synonyms: 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE;4-(2-hydroxyethyl)cyclohexan-1-one
• CAS NO: 32863-01-7
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.2
• Product Categories: Miscellaneous
• Mol File: 32863-01-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 255.3±13.0 °C(Predicted)
• Appearance: /
• Density: 1.030±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 15.06±0.10(Predicted)
• CAS DataBase Reference: 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE(32863-01-7)
• EPA Substance Registry System: 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE(32863-01-7)

Safety Data

• Hazardous Substances Data: 32863-01-7(Hazardous Substances Data)

Usage

General Description

4-(2-Hydroxy-ethyl)-cyclohexanone is a chemical compound with the molecular formula C8H14O2. It is an organic compound that contains a cyclohexanone ring with a hydroxy-ethyl group attached to the fourth carbon atom. 4-(2-HYDROXY-ETHYL)-CYCLOHEXANONE is commonly used as a building block in the synthesis of pharmaceuticals, fragrances, and other organic compounds. It is also used as a solvent in various industrial applications due to its ability to dissolve a wide range of substances. Additionally, 4-(2-Hydroxy-ethyl)-cyclohexanone is known for its mild odor and low toxicity, making it a preferred choice in many industrial processes.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 135761-76-1 2-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol 
• 74058-21-2 4-(2-Hydroxyethyl)cyclohexanol 
• 51656-91-8 ethyl 1,4-dioxaspiro[4,5]dec-8-ylideneacetate 
• 62141-26-8 ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 66405-41-2 (4-oxo-cyclohexyl)-acetic acid methyl ester 
• 58012-34-3 ethyl 4-oxocyclohexaneacetate 
• 67175-80-8 1-methoxy-4-(2-hydroxyethyl)-cyclohexa-1,4-diene 
• 501-94-0 p-hydroxyphenethyl alcohol 

Downstream Products

• 128350-17-4 2,6-bis(2-azidobenzylidene)-4-(2-hydroxyethyl)cyclohexanone 
• 606122-74-1 (4-oxocyclohexyl)acetaldehyde 
• 135761-76-1 2-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol 
• 198640-16-3 4-(2-hydroxyethyl)cyclohexanone mesylate 
• 141223-48-5 4-<(2Z)-3-(methoxycarbonyl)-2-propenyl>cyclohexan-1-one 
• 141223-49-6 4-<(2E)-3-(methoxycarbonyl)-2-propenyl>cyclohexan-1-one 
• 143949-16-0 ((E)-4-Penta-2,4-dienyl)-cyclohexanone 
• 155501-63-6 2-[1-Hydroxy-meth-(E)-ylidene]-4-((E)-penta-2,4-dienyl)-cyclohexanone 
• 143948-96-3 (E)-2-benzoyloxymethylene-4((E)-2,4-pentadienyl)cyclohexanone 
• 135761-80-7 6-(2-acetoxyethyl)-4-(2-azidophenyl)-5,6,7,8-tetrahydroquinolin-8-one 
• 128350-18-5 4-(2-acetoxyethyl)-2,6-bis(2-azidobenzylidene)cyclohexanone 
• 135761-79-4 6-(2-acetoxyethyl)-8-(2-azidobenzylidene)-4-(2-azidophenyl)-5,6,7,8-tetrahydroquinoline 
• 135761-88-5 4-(2-azidophenyl)-6-(2-aminoethyl)-5,6,7,8-tetrahydroquinolin-8-one ethylene ketal 
• 135761-85-2 4-(2-azidophenyl)-6-(2-hydroxyethyl)-5,6,7,8-tetrahydroquinolin-8-one ethylene ketal 

Relevant articles and documents

Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer. These comp

Methodology for in situ protection of aldehydes and ketones using trimethylsilyl trifluoromethanesulfonate and phosphines: Selective alkylation and reduction of ketones, esters, amides, and nitriles

A methodology for selective transformations of ketones, esters, Weinreb amides, and nitriles in the presence of aldehydes has been developed. The use of a combination of PPh3-trimethylsilyl trifluoromethanesulfonate (TMSOTf) promotes selective transformation of aldehydes to their corresponding, temporarily protected, O,P-acetal type phosphonium salts. Because, hydrolytic work-up following ensuing reactions of other carbonyl moieties in the substrates liberates the aldehyde moiety, a sequence involving aldehyde protection, transformation of other carbonyl groups, and deprotection can be accomplished in a one-pot manner. Furthermore, the use of PEt3 instead of PPh 3 enables ketones to be converted in situ to their corresponding O,P-ketal type phosphonium salts and, consequently, selective transformations of esters, Weinreb amides, and nitriles in the presence of ketones can be performed. This methodology is applicable to various dicarbonyl compounds, including substrates that possess heteroaromatic skeletons and hydroxyl protecting groups.

Chemoenzymatic preparation of functionalized bicyclo[3.2.1]octenone and practical utilization

A practical route for the synthesis of both enantiomers of a functionalized bicyclo[3.2.1]octenone, which is potentially useful as a versatile chiral building block, has been developed from 1,4-cyclohexanedione monoethylene acetal by employing proline-cat