3289-66-5Relevant articles and documents
Preparation method of 4-amino-2, 6-dimethoxypyrimidine
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Paragraph 0029; 0039; 0043; 0045; 0048; 0050; 0053, (2019/02/13)
The invention discloses a preparation method of 4-amino-2, 6-dimethoxypyrimidine in the technical field of chemical synthesis. The preparation method comprises: (1) an addition reaction: adding anhydrous methanol, a solvent and malononitrile into a container and feeding dry hydrogen chloride gas into the container for an addition reaction, (2) a condensation reaction: adding a deacidification agent into 1, 3-dimethoxypropanediamidine hydrochloride obtained in the step (1) and adding cyanamide into the mixture for a condensation reaction, (3) a cyclization reaction: adding a Lewis acid protecting agent into 3-amino-3-methoxy-N-cyano-2-propionamidine obtained in the step (2) and feeding dry hydrogen chloride gas into the mixture for a cyclization reaction, and (4) a methoxylation reaction: adding methanol and sodium hydroxide into a container, stirring and dissolving the mixture, and then adding the mixture into the 2-chloro-4-amino-6-methoxypyrimidine obtained in the step (3) for a methoxylation reaction. The preparation method is a novel method for synthesizing 4-amino-2, 6-dimethoxypyrimidine and greatly reduces the amount of discharged pollutants.
A novel synthesis of pyrimidines. II. Cyclization of alkyl N cyano cyanoacetimidates with hydrogen halides
Hirayama,Kamada,Mimura,Tsurumi
, p. 507 - 514 (2007/10/04)
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