32899-85-7

Basic information

• Product Name: 5,5-dimethyl-2-(propan-2-yl)-2,5-dihydro-1,3-thiazole
• Synonyms: 2-Isopropyl-5,5-dimethyl-2,5-dihydro-1,3-thiazole; thiazole, 2,5-dihydro-5,5-dimethyl-2-(1-methylethyl)-
• CAS NO: 32899-85-7
• Molecular Formula: C₈H₁₅NS
• Molecular Weight: 157.2764
• Mol File: 32899-85-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 229.8°C at 760 mmHg
• Flash Point: 92.8°C
• Density: 1.02g/cm³
• Vapor Pressure: 0.103mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 5,5-dimethyl-2-(propan-2-yl)-2,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-2-(propan-2-yl)-2,5-dihydro-1,3-thiazole(32899-85-7)
• EPA Substance Registry System: 5,5-dimethyl-2-(propan-2-yl)-2,5-dihydro-1,3-thiazole(32899-85-7)

Safety Data

• Hazardous Substances Data: 32899-85-7(Hazardous Substances Data)

Upstream product

• 5339-41-3 1-Isopropyl-4,4-dimethyl-2-azabutadien 
• 13206-46-7 2-bromo-2-methylpropanal 
• 78-84-2 isobutyraldehyde 
• 77144-87-7 N-isobutylidene-2-methylpropenylamine 
• 917-93-1 2-chloroisobutyraldehyde 

Downstream Products

• 13206-50-3 5,5-Dimethyl-2-isopropyl-thiazolidin-nitril-(4) 

Relevant articles and documents

Biocatalytic Reduction of 2-Monosubstituted 3-Thiazolines Using Imine Reductases

The application of a straightforward biocatalytic technology for the reduction of racemic 2-monosubstituted 3-thiazolines, which are easily prepared via Asinger-multicomponent reaction, is reported. The biocatalytic reduction yields racemic 2-monosubstituted 3-thiazolidines, which are difficult to be prepared by means of classic chemical routes, in moderate to high yields. Moreover, our study clarifies the stereochemical reaction course of the biocatalytic reduction. Furthermore, the efficiency of this biocatalytic technology is demonstrated in an experiment at an elevated substrate concentration of 60?mM leading to 96% conversion.

Practical, efficient synthesis of N-mono-substituted β-amino tertiary thiols via reductive ring-opening of 3-thiazolines

An efficient synthesis of N-mono-substituted β-amino tertiary thiols by reductive ring-opening of 3-thiazolines, obtained by use of the Asinger reaction, is described. This synthesis be regarded as a complementary approach for aminolytic ring-opening of t

Process of making penicillamine

Penicillamine and its hydrochloride are made by reacting isobutyraldehyde with elemental sulfur or a sulfur-containing compound and with gaseous ammonia so as to form 2-isopropyl-5.5-dimethyl-thiazoline-Δ3, then reacting the latter compound with substantially anhydrous hydrogen cyanide so as to form the corresponding thiazolidine 4-carbonitrile, thereupon treating the latter compound with an excess of concentrated hydrochloric acid at an elevated temperature and separating the components of the mixture formed and recovering the penicillamine hydrochloride which may then be converted to the free D,L-penicillamine.