329351-43-1 Usage
Description
3-Amino-4-carboxamidopyrazolium hydrogen sulfate is a chemical compound that serves as an important intermediate in the synthesis of triazolopyrimidines. These triazolopyrimidines are known to be potent inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (DHODH), an enzyme crucial for the growth and survival of the malaria parasite. 3-Amino-4-carboxamidopyrazolium hydrogen sulfate is highly relevant for DHODH-related research and the development of novel antimalarial agents.
Uses
Used in Pharmaceutical Research:
3-Amino-4-carboxamidopyrazolium hydrogen sulfate is used as a key intermediate in the synthesis of triazolopyrimidines for pharmaceutical research. These triazolopyrimidines are being investigated for their potential as antimalarial agents, targeting the DHODH enzyme in Plasmodium falciparum, the causative agent of malaria.
Used in Antimalarial Drug Development:
In the field of antimalarial drug development, 3-Amino-4-carboxamidopyrazolium hydrogen sulfate is utilized as a precursor for the synthesis of triazolopyrimidines. These compounds have shown significant inhibitory effects on the DHODH enzyme, which is essential for the parasite's pyrimidine de novo synthesis and plays a critical role in the parasite's survival. By inhibiting DHODH, triazolopyrimidines can effectively combat malaria infection.
Used in Enzyme Inhibition Studies:
3-Amino-4-carboxamidopyrazolium hydrogen sulfate is also used in enzyme inhibition studies, specifically focusing on the DHODH enzyme. Researchers use this compound to develop and test novel inhibitors that can effectively target and inhibit the enzyme, thereby disrupting the growth and survival of the malaria parasite. This research is vital for understanding the mechanisms of action and potential applications of these inhibitors in the treatment of malaria.
Check Digit Verification of cas no
The CAS Registry Mumber 329351-43-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,9,3,5 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 329351-43:
(8*3)+(7*2)+(6*9)+(5*3)+(4*5)+(3*1)+(2*4)+(1*3)=141
141 % 10 = 1
So 329351-43-1 is a valid CAS Registry Number.
