32946-56-8 Usage
Description
H-His(Trt)-OMe · HCl, also known as Nα-(Triphenylmethyl)-L-histidine methyl ester hydrochloride, is a chemical compound derived from L-histidine, a naturally occurring amino acid. It is characterized by the presence of a triphenylmethyl (Trt) protecting group and a methyl ester (OMe) at the N-terminus, along with a hydrochloride (HCl) counterion. H-His(Trt)-OMe · HCl is a valuable building block in the synthesis of peptides and related bioactive molecules.
Uses
Used in Peptide Synthesis:
H-His(Trt)-OMe · HCl is used as a protected amino acid building block for the synthesis of Nα-methyl-Nα-(nitrobenzenesulfonyl)amino acids and their incorporation into dipeptides. The Trt protecting group ensures that the amino acid's side chain is protected during the coupling reactions, preventing unwanted side reactions and facilitating the formation of the desired peptide bonds.
Used in Pharmaceutical Industry:
H-His(Trt)-OMe · HCl is used as a key intermediate in the synthesis of azaproline-based peptide analogs of thyrotropin-releasing hormone (TRH). These analogs have potential therapeutic applications in the treatment of various neurological disorders, such as depression and insomnia, due to their ability to modulate the release of neurotransmitters in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 32946-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,9,4 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 32946-56:
(7*3)+(6*2)+(5*9)+(4*4)+(3*6)+(2*5)+(1*6)=128
128 % 10 = 8
So 32946-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C26H25N3O2.ClH/c1-31-25(30)24(27)17-23-18-29(19-28-23)26(20-11-5-2-6-12-20,21-13-7-3-8-14-21)22-15-9-4-10-16-22;/h2-16,18-19,24H,17,27H2,1H3;1H/t24-;/m0./s1
