329710-82-9

Basic information

• Product Name: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione
• Synonyms: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione;2-(2-Trifluoromethoxy-ethyl)-isoindole-1,3-dione
• CAS NO: 329710-82-9
• Molecular Formula: C11H8F3NO3
• Molecular Weight: 259.1813296
• Mol File: 329710-82-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione(329710-82-9)
• EPA Substance Registry System: 2-(2-(trifluoroMethoxy)ethyl)isoindoline-1,3-dione(329710-82-9)

Safety Data

• Hazardous Substances Data: 329710-82-9(Hazardous Substances Data)

Usage

Type of compound

Chemical compound

Type of drug

Psychotropic drug with antipsychotic properties

Mechanism of action

Selective D2 and D3 dopamine receptor antagonist

Uses

Treatment of psychiatric disorders such as schizophrenia and bipolar disorder, reduction of aggressive and anxious behaviors in patients

Tolerance

Generally well-tolerated with minimal side effects

Research for potential use

Treatment of substance abuse and addiction

Therapeutic potential

Promising compound for the management of psychiatric conditions, with ongoing research exploring its potential.

Upstream product

• 1074-82-4 potassium phtalimide 
• 329710-76-1 2-(trifluoromethoxy)ethyl trifluoromethanesulphonate 
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• 127175-39-7 2-(1,3-dioxoisoindolin-2-yl)ethyl trifluoromethanesulfonate 
• 40149-83-5 2-(2-iodoethyl)isoindoline-1,3-dione 
• 1006904-72-8 silver(I) trifluoromethoxide 
• 887144-94-7 Togni's reagent II 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 79410-57-4 Nonafluorobutansulfonsaeure-trifluormethylester 

Downstream Products

• 886050-51-7 2-(trifluoromethoxy)ethylamine hydrochloride 

Relevant articles and documents

Evaluation of efficient and practical methods for the preparation of functionalized aliphatic trifluoromethyl ethers

The "chlorination/fluorination" technique for aliphatic trifluoromethyl ether synthesis was investigated and a range of products with various functional groups was prepared. The results were compared with oxidative desulfurization-fluorination of xanthates with the same structure.

Synthesis of trifluoromethyl ethers and difluoro(methylthio)methyl ethers by the reaction of dithiocarbonates with IF5-pyridine-HF

Trifluoromethyl ether and difluoro(methylthio)methyl ether of phenols and aliphatic alcohols were selectively synthesized from the corresponding dithiocarbonates. When IF5-pyridine-HF was used alone in the reaction of the dithiocarbonate, the difluoro(methylthio)methyl ether was selectively formed. On the other hand, by the additional use of Et3N-6HF with IF5-pyridine-HF, trifluoromethyl ether was formed selectively. Various functional groups such as ester, ether, amide, and acetonide could tolerate the reaction conditions, and various functionalized difluoro(methylthio)methyl ethers and trifluoromethyl ethers were synthesized.

Versatile application of trifluoromethyl triflate

Hydrolytically stable and easy to handle trifluoromethyl triflate was found to be a liquid reservoir of 'masked' difluorophosgene. Anhydrous F- sources cleave the S-O bond in trifluoromethyl triflate yielding quantitatively the trifluoromethanolate salts, being useful trifluoromethoxy group carriers. Reaction of trifluoromethanolates with in situ generated from o-trimethylsilylphenyl triflate benzyne leads to (trifluoromethoxy)benzene and fluorobenzene (ratio 85:15). Whereas an addition of trifluoromethanethiolate anion across a triple bond of benzyne leads to [(trifluoromethyl)sulfanyl]benzene solely.