329744-59-4

Basic information

• Product Name: Benzonitrile, 3-fluoro-4-[(1E,3E)-5-oxo-1,3-pentadienyl]-
• CAS NO: 329744-59-4
• Molecular Formula: C12H8FNO
• Molecular Weight: 201.2
• Mol File: 329744-59-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-fluoro-4-[(1E,3E)-5-oxo-1,3-pentadienyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-fluoro-4-[(1E,3E)-5-oxo-1,3-pentadienyl]-(329744-59-4)
• EPA Substance Registry System: Benzonitrile, 3-fluoro-4-[(1E,3E)-5-oxo-1,3-pentadienyl]-(329744-59-4)

Safety Data

• Hazardous Substances Data: 329744-59-4(Hazardous Substances Data)

Upstream product

• 170572-49-3 2-fluoro-4-cyanotoluene 
• 105942-09-4 4-(bromomethyl)-3-fluorobenzonitrile 
• 329744-44-7 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile 
• 329744-58-3 diethyl 4-cyano-2-fluorobenzylphosphonate 

Downstream Products

• 329744-44-7 4-[(1E,3E)-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]-1,3-butadienyl]-3-fluorobenzonitrile 
• 329744-48-1 (2R,3R)-3-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadien-1-yl]-1,3-dioxan-5-yl]thio]-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 329744-47-0 (2R,3R)-3-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadien-1-yl]-1,3-dioxan-5-yl]thio]-2-(2,3-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 329744-46-9 (2R,3R)-3-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadien-1-yl]-1,3-dioxan-5-yl]thio]-2-(4-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 329744-45-8 (2R,3R)-3-[[trans-2-[(1E,3E)-4-(4-cyano-2-fluorophenyl)-1,3-butadien-1-yl]-1,3-dioxan-5-yl]thio]-2-(2-fluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 

Relevant articles and documents

Mechanistic study of the oxidative degradation of the triazole antifungal agent CS-758 in an amorphous form

In this study, the degradates generated from a pharmaceutical solid were characterized, and a mechanistic pathway underlying their formation was proposed. The chemical stability of a novel triazole antifungal drug, CS-758, deteriorated significantly when the crystal was disordered, and characteristic degradates were generated. A total of eight degradates in solution and nine degradates in a solid state were isolated by preparative liquid chromatography. Degradates were characterized using high-performance liquid chromatography-photodiode array, mass spectrometry, and nuclear magnetic resonance. Radical-mediated oxidation is proposed as the main degradation pathway in the solid state. The initiation step of this pathway is hydrogen atom abstraction from a methine carbon that is adjacent to a dien moiety and the formation of a delocalized vinylic radical intermediate. Molecular oxygen is then added to the radical position to form hydroperoxides. There are three potential oxidation routes based on the proposed autoxidation pathway that lead to the generation of the dioxane ring-opening hydroxyl form, the 9,10-epoxide form, or the 11,12-epoxide form, depending on the substituted position of the added molecular oxygen. The epimer compound generated via the vinylic radical intermediate and sulfoxides was characterized. This degradation mechanism provides the scientific foundation for an oxidative stressing system currently under investigation.

Synthesis and in vitro antifungal activities of novel triazole antifungal agent CS-758

Synthesis and in vitro antifungal activities of a novel triazole antifungal agent CS-758 (former name, R120758) are described. The minimum inhibitory concentrations (MICs) of a series of dioxane-triazole compounds related to R-102557 were examined. Variat