330-59-6

Basic information

• Product Name: N-(4-fluorophenyl)-3-(trifluoromethyl)aniline
• Synonyms: N-(4-fluorophenyl)-3-(trifluoromethyl)aniline
• CAS NO: 330-59-6
• Molecular Weight: 255.215
• Mol File: 330-59-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-fluorophenyl)-3-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorophenyl)-3-(trifluoromethyl)aniline(330-59-6)
• EPA Substance Registry System: N-(4-fluorophenyl)-3-(trifluoromethyl)aniline(330-59-6)

Safety Data

• Hazardous Substances Data: 330-59-6(Hazardous Substances Data)

Upstream product

• 371-41-5 4-Fluorophenol 
• 98-16-8 3-trifluoromethylaniline 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 460-00-4 1-Bromo-4-fluorobenzene 

Relevant articles and documents

Use of a "catalytic" Cosolvent, N,N-Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch

A general, efficient method for C-N cross-coupling has been developed using N,N-dimethyloctanamide as a catalytic cosolvent for biphasic continuous-flow applications. The described method was used to generate a variety of biarylamines and was integrated into a two-step sequence which converted phenols into biarylamines via either triflates or tosylates. Additionally, the method was applied to a three-step synthesis of imatinib, the API of Gleevec, in good yield without the need of solvent switches. Going with the flow: A general flow method developed for C-N cross-coupling using N,N-dimethyloctanamide as a catalytic cosolvent was integrated into a two-step sequence which converted phenols into biarylamines via either triflates or tosylates. It was applied to a three-step synthesis of imatinib, the API of Gleevec, in good yield without the need of solvent switches.