330-88-1 Usage
Description
(4-methoxyphenyl)-phenyl-iodanium; 2,2,2-trifluoroacetic acid is a combination of two distinct chemical compounds, (4-methoxyphenyl)-phenyl-iodanium and 2,2,2-trifluoroacetic acid. The former is a phenyl-iodanium cation with a 4-methoxyphenyl group, which serves as an oxidizing agent in organic synthesis and participates in reactions such as aromatic substitution and cross-coupling. The latter, 2,2,2-trifluoroacetic acid, is a strong organic acid used as a solvent, catalyst, and reagent in the pharmaceutical industry, known for protonating basic compounds and acting as a deprotecting agent in organic chemistry. Together, they form a versatile reagent with applications in various chemical processes.
Uses
Used in Organic Synthesis:
(4-methoxyphenyl)-phenyl-iodanium; 2,2,2-trifluoroacetic acid is used as a reagent in organic synthesis for its ability to act as an oxidizing agent and participate in various reactions such as aromatic substitution and cross-coupling reactions. This allows for the formation of new chemical bonds and the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-methoxyphenyl)-phenyl-iodanium; 2,2,2-trifluoroacetic acid is used as a reagent and catalyst for its ability to protonate basic compounds and act as a deprotecting agent in organic chemistry. This aids in the synthesis of pharmaceutical compounds and the development of new drugs.
Used in Solvent Applications:
(4-methoxyphenyl)-phenyl-iodanium; 2,2,2-trifluoroacetic acid is used as a solvent in various chemical processes due to its strong acidic properties, which enable it to dissolve a wide range of substances and facilitate reactions.
Used in Catalyst Applications:
As a catalyst, (4-methoxyphenyl)-phenyl-iodanium; 2,2,2-trifluoroacetic acid is used to increase the rate of chemical reactions without being consumed in the process. This allows for more efficient synthesis and production of desired compounds in the chemical and pharmaceutical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 330-88-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 330-88:
(5*3)+(4*3)+(3*0)+(2*8)+(1*8)=51
51 % 10 = 1
So 330-88-1 is a valid CAS Registry Number.
330-88-1Relevant articles and documents
Palladium-Catalyzed Four-Component Carbonylative Cyclization Reaction of Trifluoroacetimidoyl Chlorides, Propargyl Amines, and Diaryliodonium Salts: Access to Trifluoromethyl-Containing Trisubstituted Imidazoles
Chen, Zhengkai,Wang, Wei-Feng,Yang, Hefei,Wu, Xiao-Feng
supporting information, p. 1980 - 1984 (2020/03/04)
A palladium-catalyzed four-component carbonylative cyclization reaction for the expeditious construction of trifluoromethyl-containing trisubstituted imidazoles has been achieved. With readily accessible trifluoroacetimidoyl chlorides, propargyl amines, a
Facile One-Pot Synthesis of Diaryliodonium Salts from Arenes and Aryl Iodides with Oxone
Soldatova, Natalia,Postnikov, Pavel,Kukurina, Olga,Zhdankin, Viktor V.,Yoshimura, Akira,Wirth, Thomas,Yusubov, Mekhman S.
, p. 18 - 20 (2017/02/10)
A straightforward synthesis of diaryliodonium salts is achieved by using Oxone as the stoichiometric oxidant. Slow addition is the key to obtaining good yields and purities of the reaction products, which are highly useful reagents in many different areas of organic synthesis.
Arylation of anilines: formation of diarylamines using diaryliodonium salts
Carroll, Michael A.,Wood, Reice A.
, p. 11349 - 11354 (2008/03/12)
Extensive studies on the reaction of the fluoride ion with diaryliodonium salts demonstrated that this is a generic process for the formation of fluoroarenes and has particular advantages for the preparation of fluorine-18 radiopharmaceuticals. During these studies it became apparent that nucleophiles other than the fluoride ion may be employed for generating substituted aromatics. This approach can be applied, using substituted anilines as the nucleophilic reagent, to the formation of a range of diarylamines in good yield. Optimised conditions for the reaction of a diaryliodonium salt with an aniline utilise TFA as the preferred counter-ion in DMF (130 °C, 24 h).
