33026-82-3Relevant articles and documents
Reactive intermediates in the H-phosphonate synthesis of oligonucleotides
Powles, Nicholas,Atherton, John,Page, Michael I.
, p. 5940 - 5947 (2012)
The formation of H-phosphonate diesters is an important step in the synthesis of oligonucleotides. Using diphenylchlorophosphate as the activator for the coupling step is often accompanied by side reactions as a result of self 'capping' and other reactions of the reactive intermediate. In the absence of base, the activation of ethyl H-phosphonate with diphenylchlorophosphate probably occurs through the intermediate formation of bis diethyl pyro-di-H-phosphonate rather than the expected diphenyl ethyl pyro-H-phosphonate. Pyridine acts as a nucleophilic catalyst converting diphenylchlorophosphate to its pyridinium adduct. Several side and unwanted reactions are quantified so that conditions to minimise these can be identified.
NOUVEAUX TRIOXOPHOSPHETANES GENERATEURS D'OXYGENE SINGULET A BASSE TEMPERATURE
Khatib, Fayez El,Tachon, Christine,Caminade, Anne-Marie,Koenig, Max
, p. 3007 - 3010 (2007/10/02)
We have prepared phosphite ozonides 1b-3b which are efficient and clean singlet oxygene generators at low temperature.
