330555-58-3

Basic information

• Product Name: Butanamide, 3-hydroxy-4-(triphenylmethoxy)-, (3S)-
• CAS NO: 330555-58-3
• Molecular Formula: C23H23NO3
• Molecular Weight: 361.441
• Mol File: 330555-58-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanamide, 3-hydroxy-4-(triphenylmethoxy)-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 3-hydroxy-4-(triphenylmethoxy)-, (3S)-(330555-58-3)
• EPA Substance Registry System: Butanamide, 3-hydroxy-4-(triphenylmethoxy)-, (3S)-(330555-58-3)

Safety Data

• Hazardous Substances Data: 330555-58-3(Hazardous Substances Data)

Upstream product

• 126495-84-9 (S)-3,4-dihydroxybutyramide 
• 76-83-5 trityl chloride 
• 65291-30-7 trityl glycidyl ether 
• 890050-54-1 3-hydroxy-4-triphenylmethoxybutanenitrile 
• 131666-63-2 (S)-3-hydroxy-4-triphenylmethoxybutanenitrile 

Downstream Products

• 637343-45-4 (S)-3-(2,5-dimethoxyphenacyl)-5-trityloxymethyl-2-oxazolidinone 
• 637343-44-3 (S)-3-(2-nitrophenyl)-5-trityloxymethy-2-oxazolidinone 
• 637343-48-7 n-isopropyl-5-trityloxymethyl-2-oxazolidinone 
• 841261-74-3 (2S)-4-amino-1-(triphenylmethoxy)-2-butanol 
• 330555-60-7 (S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one 

Relevant articles and documents

A simple three-step method for preparing homochiral 5-trityloxymethyl-2-oxazolidinones from optically active 3-hydroxy-γ-butyrolactones

A simple high-yield three-step route to O-tritylated optically active 5-hydroxymethyl oxazolidinones from optically active 3-hydroxy-γ-butyrolactones is described. The key intermediate is the 4-O-trityl ether of homochiral 3,4-dihydroxybutyramide, which is obtained in quantitative yield from 3-hydroxy-γ-butyrolactone by treatment with ammonia. It is readily transformed to the oxazolidinone by Hoffmann rearrangement in a two-phase system. The carbonyl group in the oxazolidinone is derived from C-1 of the amide, and a separate carbonylation reaction is not required. Oxazolidinones are key compounds in drug synthesis especially in the areas of antibacterials and behavior disorder therapy.

Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera

PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF

A process for preparing N-(substituted)-C-- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C-- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)- oxazolidi