330792-86-4

Basic information

• Product Name: 2-(4-IODOPHENOXY)PYRIMIDINE
• Synonyms: 2-(4-IODOPHENOXY)PYRIMIDINE;4-iodophenyl 2-pyrimidinyl ether
• CAS NO: 330792-86-4
• Molecular Formula: C₁₀H₇IN₂O
• Molecular Weight: 298.08
• Mol File: 330792-86-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 87-90°
• Appearance: /
• CAS DataBase Reference: 2-(4-IODOPHENOXY)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-IODOPHENOXY)PYRIMIDINE(330792-86-4)
• EPA Substance Registry System: 2-(4-IODOPHENOXY)PYRIMIDINE(330792-86-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 330792-86-4(Hazardous Substances Data)

Usage

Structure

Pyrimidine derivative with a phenyl group substituted at the 2 position and an iodine atom at the 4 position

Type of compound

Chemical compound

Potential use

Pharmaceutical research, development of new drugs for various medical conditions

Unique properties

Makes it a candidate for further investigation as a potential drug candidate or as a building block for the synthesis of other biologically active compounds

Additional research needed

To fully understand its potential applications and effects.

Upstream product

• 18213-90-6 2-phenoxypyrimidine 
• 1722-12-9 2-chloropyrimidine 
• 540-38-5 p-Iodophenol 

Downstream Products

• 894400-06-7 2-(4-iodophenoxy)-5-ethylpyrimidine 

Relevant articles and documents

C(sp3)-H Monoarylation of Methanol Enabled by a Bidentate Auxiliary

With the assistance of a practical directing group (COAQ), the first catalytic protocol for the palladium-catalyzed C(sp3)-H monoarylation of methanol has been developed, offering an invaluable synthesis means to establish extensive derivatives of crucial arylmethanol functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional group compatibility, and even the practical synthesis of medicines further demonstrate the usefulness of this strategy.

THERAPEUTIC OR PROPHYLACTIC AGENT FOR ALLERGIC DERMATITIS

A therapeutic or prophylactic agent for allergic dermatitis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for allergic dermatitis according to the present invention has high therapeutic or prophylactic effect.

GLYCINE DERIVATIVE AND USE THEREOF

The compounds in the present invention, for example, the compound represented by the formula: has an excellent therapeutic and prophylactic effects against inflammatory bowel disease. Further, they are excellent in absorption and in vivo stability when administered orally in comparison with conventional compounds. That is, the compounds can be administered orally, and can have excellent therapeutic or prophylactic effect sustained for a longer period of time.