3309-47-5

Basic information

• Product Name: ((cyclohexyloxy)carbonyl)-1-leucine
• Synonyms: ((cyclohexyloxy)carbonyl)-1-leucine
• CAS NO: 3309-47-5
• Molecular Weight: 257.33
• Mol File: 3309-47-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ((cyclohexyloxy)carbonyl)-1-leucine(CAS DataBase Reference)
• NIST Chemistry Reference: ((cyclohexyloxy)carbonyl)-1-leucine(3309-47-5)
• EPA Substance Registry System: ((cyclohexyloxy)carbonyl)-1-leucine(3309-47-5)

Safety Data

• Hazardous Substances Data: 3309-47-5(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 13248-54-9 cyclohexyl chloroformate 
• 328-39-2 LEUCINE 
• 108-93-0 cyclohexanol 
• 30293-88-0 N-carbonyl-L-leucine methyl ester 
• 172922-30-4 (S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoic acid benzyl ester 

Downstream Products

• 1027972-65-1 2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid benzyl ester 
• 1026125-88-1 2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester 

Relevant articles and documents

BROAD SPECTRUM ANTIVIRALS AGAINST CORONAVIRUS

Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2/sub

Cyclohexyloxycarbonyl based orthogonal solid phase peptide synthesis in Boc chemistry

Application of N-cyclohexyloxocarbonyl (Choc) protection in Boc chemistry on solid phase provides a new possibility for the preparation of protected peptide fragments. A Choc/OcHex protection scheme allows also the assembly of cyclic lactam peptides linked to the resin through the C- terminus. Choc protection is stable under the 1M TMSOTf-thioanisole/TFA cleavage condition at 0°C, but it is removable by anhydrous HF. We have utilized cyclohexyloxycarbonyl as an orthogonal protecting group for the synthesis of a i) bicyclic epitope peptide of glycoprotein D of HSV 1 on BHA resin and ii) fully protected hexapeptide involved in protein transport on Merrifield resin.