33098-11-2

Basic information

• Product Name: 4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One
• Synonyms: 4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One
• CAS NO: 33098-11-2
• Molecular Formula: C₁₀H₅Cl₃N₂O
• Molecular Weight: 275.5185
• Mol File: 33098-11-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 186-188 °C(Solv: ethanol (64-17-5))
• Boiling Point: 353.0±52.0 °C(Predicted)
• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• PKA: -4.22±0.60(Predicted)
• CAS DataBase Reference: 4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One(33098-11-2)
• EPA Substance Registry System: 4,5-Dichloro-2-(4-Chlorophenyl)-2,3-Dihydropyridazin-3-One(33098-11-2)

Safety Data

• Hazardous Substances Data: 33098-11-2(Hazardous Substances Data)

Upstream product

• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 108-90-7 chlorobenzene 
• 766-40-5 Mucochloric acid 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 57697-64-0 mucochloric acid 

Downstream Products

• 64178-70-7 4-chloro-2-(4-chloro-phenyl)-5-hydroxy-2H-pyridazin-3-one 
• 220088-52-8 C₁₇H₁₂Cl₂N₂O₃ 

Relevant articles and documents

Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue

Aberrant fibrogenesis is a feature of many diseases in multiple organ systems. The lysyl oxidase family of enzymes are central to tissue homeostasis and elevated lysyl oxidase activity is implicated in fibroproliferation as well as in cancer stroma. We have synthesised a novel fluorogenic reporter for monitoring lysyl oxidase activity that generates a 3-5 fold increase in fluorescence following probe activation in ventilating fibrotic ex vivo asinine lung and ex vivo human lung tissue. The probe termed "oLOX" can provide real-time measurement of lysyl oxidase activity in a number of biological settings and is tractable from an in vitro setting to man.

Efficient N-arylation of pyridazin-3(2H)-ones

A variety of substituted pyridazin-3(2H)-ones are directly N-arylated in good yield using lead tetraacetate/zinc chloride in benzene or in substituted benzenes including chloro- and bromobenzene. A variety of substituted pyridazin-3(2H)-ones are directly N-arylated in good yield using lead tetraacetate/zinc chloride in benzene or in substituted benzenes including chloro- and bromobenzene.