331-05-5

Basic information

• Product Name: phenylacetic trifluoroacetic anhydride
• Synonyms: phenylacetic trifluoroacetic anhydride
• CAS NO: 331-05-5
• Molecular Weight: 232.159
• Mol File: 331-05-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: phenylacetic trifluoroacetic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: phenylacetic trifluoroacetic anhydride(331-05-5)
• EPA Substance Registry System: phenylacetic trifluoroacetic anhydride(331-05-5)

Safety Data

• Hazardous Substances Data: 331-05-5(Hazardous Substances Data)

Upstream product

• 1555-80-2 phenylacetic anhydride 
• 407-25-0 trifluoroacetic anhydride 
• 103-82-2 phenylacetic acid 
• 2966-50-9 silver trifluoroacetate 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1187323-13-2 4-cyclohexyltetralen-2-ol phenylacetate 
• 1254803-06-9 4-cyclohexyl-3,4-dihydronaphthalen-2(1H)-one 
• 918331-44-9 17β-methyl-16β-phenyl-17α-phenylacetoxy-D-homoandrost-4,6-diene-3,17a-dione 
• 3377-89-7 t-butyl phenylperacetate 
• 93534-10-2 3-benzyl-6,8-dichloro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 
• 3966-97-0 3-benzyl-7-chloro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 

Relevant articles and documents

Clean-chemistry synthesis of 2-tetralones in a single-stage acylation - Cycloalkylation process

The preparation of substituted-2-tetralones by direct reaction of a 1-alkene with a substituted phenylacetic acid in a reaction system of trifluoroacetic anhydride (TFAA) and phosphoric acid is described. This single-stage process involves in situ formation of a mixed anhydride of the phenylacetic acid and acylation of the alkene by this species followed by cycloalkylation of the aromatic ring. This is a cleaner approach to the synthesis of 2-tetralones compared to Friedel-Crafts aliphatic acylation-cycloalkylation in that use of thionyl chloride, aluminum trichloride, and a chlorinated hydrocarbon solvent is eliminated. In addition, the atom efficiency is augmented by recovery of the spent TFAA as trifluoroacetic acid (TFA) and conversion of this back to TFAA by dehydration.

THERAPEUTIC COMPOUNDS

The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and dis

Acylation of Ferrocene and a 1,1′-Diphosphaferrocene with Acyl Trifluoroacetates in the Presence of Trifluoromethanesulfonic (Triflic) Acid or Some Metal Triflates

Ferrocene and 3,3′,4,4′-tetramethyl-1,1′ -diphosphaferrocene undergo efficient acylation by acyl trifluoroacetates (prepared in situ from carboxylic acids and trifluoroacetic anhydride) in the presence of an excess of trifluoromethanesulfonic acid or cata