33107-83-4

Basic information

• Product Name: 2-Propanone, 1-chloro-3-(4-chlorophenyl)-
• CAS NO: 33107-83-4
• Molecular Formula: C9H8Cl2O
• Molecular Weight: 203.068
• Mol File: 33107-83-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propanone, 1-chloro-3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanone, 1-chloro-3-(4-chlorophenyl)-(33107-83-4)
• EPA Substance Registry System: 2-Propanone, 1-chloro-3-(4-chlorophenyl)-(33107-83-4)

Safety Data

• Hazardous Substances Data: 33107-83-4(Hazardous Substances Data)

Upstream product

• 21443-38-9 1-(4-chlorophenyl)-3-diazo-propan-2-one 
• 1878-66-6 4-chlorophenylacetic Acid 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 2549-51-1 vinyl chloroacetate 
• 96-34-4 methyl chloroacetate 
• 105-39-5 chloroacetic acid ethyl ester 
• 186581-53-3 diazomethane 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 56955-38-5 3-(4-chlorophenyl)-2-oxopropyl acetate 
• 924633-96-5 3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester 
• 851547-06-3 9-Benzyl-2-(4-chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid 
• 851548-07-7 3-acetoxy-9-acetyl-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid 
• 851547-04-1 2-(4-Chloro-benzyl)-3-hydroxy-9-isopropyl-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid 
• 851547-08-5 2-(4-Chloro-benzyl)-9-ethyl-3-hydroxy-7,8,9,10-tetrahydro-[1,9]phenanthroline-4-carboxylic acid 

Relevant articles and documents

A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant

α-Halogenated ketones are both unique structure moieties existing in biologically natural products and valuable synthetic intermediates for the preparation of functional molecules. An efficient and scalable method for the preparation of α-halogenated ketone using iron (III) chloride and iron (III) bromide as halogen sources with phenyliodonium diacetate as oxidant has been developed, featuring mild reaction conditions, environmentally friendly reagents, and wide substrate scope. Notably, the three-step synthesis of drug prasugrel was achieved using this developed method as a key step with 30% yield on gram-scale. Additionally, the reaction mechanism involving chloride cation was proposed based on some preliminary control experiments. (Figure presented.).

Methods and Compositions for Treatment of Scleritis and Related Disorders

The present teachings relate to the field of anti-inflammatory substances and more particularly to compounds that are useful for the treatment of scleritis, a scleritis symptom, or a scleritis-related disorder. In one aspect, methods of treating scleritis, a scleritis symptom, or a scleritis-related disorder generally include administering to a subject a compound of Formula I: or a pharmaceutically acceptable salt, hydrate or ester thereof, wherein W1, W2, R1, L, X, Y, Z, and n1 are defined as described herein.

METHOD FOR PRODUCING 1-HALO-3-ARYL-2-PROPANONE

1-halo-3-aryl-2-propanone can be produced with ease and with good efficiency without the use of a reagent being difficult to handle or the equipment for a super low temperature reaction, by using a method comprising reacting an enolate prepared from an arylacetic acid or an arylacetic acid derivative, which is inexpensive and easily available, and a base, with a haloacetic acid derivative, which is inexpensive and easily available, followed by the treatment with an acid. 1-halo-3-aryl-2-propanone is useful as a pharmaceutical intermediate or the like.