33143-80-5

Basic information

• Product Name: 4-(PROP-2-YNYLOXY)BENZONITRILE
• Synonyms: 4-(PROP-2-YNYLOXY)BENZONITRILE;3-(4-CYANOPHENOXY)PROP-1-YNE;4-prop-2-ynoxybenzonitrile
• CAS NO: 33143-80-5
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.16868
• Mol File: 33143-80-5.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(PROP-2-YNYLOXY)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PROP-2-YNYLOXY)BENZONITRILE(33143-80-5)
• EPA Substance Registry System: 4-(PROP-2-YNYLOXY)BENZONITRILE(33143-80-5)

Safety Data

• Hazardous Substances Data: 33143-80-5(Hazardous Substances Data)

Upstream product

• 767-00-0 4-cyanophenol 
• 106-96-7 propargyl bromide 
• 5651-86-5 4-(prop-2-ynyloxy)benzaldehyde 
• 34905-02-7 [4-(prop-2-yn-1-yloxy)phenyl]methanol 
• 1079882-90-8 1-(azidomethyl)-4-(prop-2-yn-1-yloxy)benzene 
• 107-19-7 propargyl alcohol 
• 619-72-7 4-nitrobenzonitrile 
• 2450-71-7 Propargylamine 

Downstream Products

• 943026-55-9 (4-(prop-2-yn-1-yloxy)phenyl)methanamine 
• 943026-56-0 N-acetyl-4-(2-propynyloxy)benzylamine 
• 1003001-05-5 4-((1-phenyl-1H-[1,2,3]-triazol-5-yl)methoxy)benzonitrile 
• 216482-60-9 1-(4-cyanophenoxymethyl)-1,2-dicarba-closo-dodecaborane⁽¹²⁾ 
• 1196658-71-5 1-(3,4,6-tri-O-acetyl-1,5-anhydro-2-deoxy-D-galactitol-2-yl)-4-(4-cyanophenoxy)methyl-1,2,3-triazole 
• 16238-12-3 2-methylbenzofuran-5-carbonitrile 
• 33143-95-2 2H-1-benzopyran-6-carbonitrile 
• 1334667-34-3 1-(4,4'-dicyanodiphenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 1334667-59-2 1-(4-cyanophenylmethyl)-4-((4-cyanophenoxy)methyl)-1H-1,2,3-triazole 
• 1352840-39-1 C₂₀H₁₉NO₂ 
• 1352840-47-1 C₄₀H₄₇N₉O₂ 
• 1393750-83-8 C₂₈H₂₉F₂N₅O₁₀ 
• 1383455-15-9 3-(N-benzylisoindolin-1-onyl)-6-cyano-4-phenyl-2H-chromene 
• 1383455-03-5 3-(4-cyanophenoxy)-1-phenylprop-1-yne 

Relevant articles and documents

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

Synthesis of alkynylated 1,2,4-oxadiazole/1,2,3-1H-triazole glycoconjugates: Discovering new compounds for use in chemotherapy against lung carcinoma and Mycobacterium tuberculosis

A total of forty-three compounds were synthesized, including thirty-two new ones. Among those compounds, seventeen were selected and tested on human tumor cell lines: PC-3 (prostate adenocarcinoma), HCT-116 (colorectal tumor), NCIH-460 (lung carcinoma), S

Amidine-and amidoxime-substituted heterocycles: Synthesis, antiproliferative evaluations and dna binding

The novel 1,2,3-triazolyl-appended N-and O-heterocycles containing amidine 4–11 and amidoxime 12–22 moiety were prepared and evaluated for their antiproliferative activities in vitro. Among the series of amidine-substituted heterocycles, aromatic diamidin