33172-54-2Relevant articles and documents
Facile one-pot transformation of phenols into o-cyanophenols
Nakai, Yuhta,Moriyama, Katsuhiko,Togo, Hideo
, p. 6077 - 6083 (2015/03/30)
The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors
Matos, Maria Jo?o,Vi?a, Dolores,Janeiro, Patricia,Borges, Fernanda,Santana, Lourdes,Uriarte, Eugenio
scheme or table, p. 5157 - 5160 (2010/10/21)
With the aim to find out the structural features for the MAO inhibitory activity and selectivity, in the present communication we report the synthesis and pharmacological evaluation of a new series of bromo-6-methyl-3- phenylcoumarin derivatives (with bro
Ligand tuning in the chromium-salen-mediated asymmetric epoxidation of alkenes
McGarrigle,Murphy,Gilheany
, p. 1343 - 1354 (2007/10/03)
A series of Cr(salen) complexes have been synthesised from 5-substituted-3-bromosalicylaldehydes and trans-1,2-cyclohexanediamine. These have been used to probe the Cr(salen)-mediated asymmetric epoxidation of alkenes. No simple correlation was found between the electronic character of the salen-substituents and the enantioselectivity - multiple oxidation pathways are proposed as a possible explanation. Enantioselectivities of up to 90% have been achieved using a novel, synthetically accessible Cr(salen) complex.