331763-66-7

Basic information

• Product Name: BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID
• Synonyms: RARECHEM AK PT B068;N-T-BUTOXYCARBONYL-(R)-3-AMINO-4-(3-FLUOROPHENYL)BUTANOIC ACID;N-BETA-T-BUTOXYCARBONYL-D-HOMO(3-FLUOROPHENYL)ALANINE;BOC-D-PHE(3-F)-(C*CH2)OH;BOC-3-FLUORO-D-BETA-HOMOPHENYLALANINE;BOC-D-BETA-HOPHE(3-F)-OH;BOC-(R)-3-AMINO-4-(3-FLUOROPHENYL)BUTANOIC ACID;BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID
• CAS NO: 331763-66-7
• Molecular Formula: C₁₅H₂₀FNO₄
• Molecular Weight: 297.32
• Product Categories: 3-Amino-4-phenylbutyric Acid Analogs;3-Amino-4-phenylbutanoic Acid Analogs;B-Amino
• Mol File: 331763-66-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 443.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.192
• Storage Temp.: 2-8°C
• PKA: 4.40±0.10(Predicted)
• CAS DataBase Reference: BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID(331763-66-7)
• EPA Substance Registry System: BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID(331763-66-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 331763-66-7(Hazardous Substances Data)

Usage

General Description

BOC-(R)-3-AMINO-4-(3-FLUORO-PHENYL)-BUTYRIC ACID is a chemical compound often used in scientific research. This chemical, often shortened to BOC, has a complex structure featuring an amino group, a four-carbon butyric acid chain, and a fluorophenyl group. The (R) notation indicates it is a particular isomer or form of the molecule. The presence of fluorine atoms contributes to its reactivity, and the BOC group is often used in chemistry to protect the amino group during reactions. The precise properties and uses of this chemical can depend on the exact context and reaction conditions.

Upstream product

• 114873-11-9 boc-L-3-(3-fluorophenyl)alanine 

Relevant articles and documents

Synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid

The invention relates to a synthesis method of chiral N-Boc-3-amino-4-aryl-butyric acid. The method is as below: 1, conducting a cross metathesis reaction, an asymmetric conjugate addition reaction and an oxidation reaction on starting materials including an allyl aromatic compound and crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; or conducting an asymmetric conjugate addition reaction and an oxidation reaction on a starting material (E)-4-aryl-2-crotonaldehyde by a continuous reaction one-pot method to synthesize an N-Boc-3-aryl methyl-5-oxo isoxazole intermediate; and 2, subjecting (3R)-N-Boc-3-aryl methyl-5-oxo isoxazole intermediate by high-pressure hydrogenation to directly prepare the chiral N-Boc-3-amino-4-aryl-butyric acid. The synthesis method provided by the invention has the advantages of simple operation, mild reaction conditions, target product yield reaching 60-69%, and ee value of the target product reaching as high as 96%. The synthetic route has industrialization prospect.