331846-97-0

Basic information

• Product Name: (S)-3-AMino-(6-phenyl)-5-hexenoic acid-HCl
• Synonyms: (S)-3-Amino-5-phenyl-pentanoic acida€￠HCl
• CAS NO: 331846-97-0
• Molecular Formula: C12H16ClNO2
• Molecular Weight: 241.71394
• Mol File: 331846-97-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (S)-3-AMino-(6-phenyl)-5-hexenoic acid-HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMino-(6-phenyl)-5-hexenoic acid-HCl(331846-97-0)
• EPA Substance Registry System: (S)-3-AMino-(6-phenyl)-5-hexenoic acid-HCl(331846-97-0)

Safety Data

• Hazardous Substances Data: 331846-97-0(Hazardous Substances Data)

Usage

Description

(S)-3-Amino-(6-phenyl)-5-hexenoic acid-HCl is an organic compound characterized by the presence of an amino group, a phenyl group, and a hexenoic acid group, along with a hydrochloride (HCl) salt. (S)-3-AMino-(6-phenyl)-5-hexenoic acid-HCl is utilized in the pharmaceutical and medicinal chemistry sectors due to its unique structure and properties, which make it a versatile building block for the synthesis of various pharmaceutical compounds. Its specific characteristics and interactions with biological systems render it a valuable asset in the research and development of novel medications.

Uses

Used in Pharmaceutical Industry:
(S)-3-Amino-(6-phenyl)-5-hexenoic acid-HCl is used as a building block for the synthesis of pharmaceutical compounds, given its unique structure and properties. It contributes to the development of new drugs by providing a foundation for chemical modifications and enhancements.
Used in Medicinal Chemistry Research and Development:
In the field of medicinal chemistry, (S)-3-Amino-(6-phenyl)-5-hexenoic acid-HCl is employed as a key component in the production of potential new drugs. Its specific properties and effects on biological systems make it an essential tool for understanding and developing innovative medications to address various health conditions.

Upstream product

• 1090904-04-3 (S)-3-amino-5-phenylpentanoic acid 
• 104-53-0 3-phenyl-propionaldehyde 
• 543700-16-9 3-benzyloxycarbonylamino-5-phenyl-pentanoic acid ethyl ester 

Relevant articles and documents

Improved enzymatic syntheses of valuable β-arylalkyl-β-amino acid enantiomers

The enantioselective (E～ 200) Burkholderia cepacia-catalysed hydrolyses of β-amino esters with H2O (0.5 equiv.) in t-BuOMe or in i-Pr2O at 45 °C are described. The enantiomers of biologically relevant β-arylalkyl-substituted β-amino acids, and especially (R)-3-amino-3-(2,4,5-trifluorophenyl)butanoic acid, the intermediate of the new antidiabetic drug sitagliptine, were prepared with high enantiomeric excesses (ee≥96%) and in good yields (≥42%). The Royal Society of Chemistry 2010.

N-, α-, and β-substituted 3-aminopropionic acids: Design, syntheses and antiseizure activities

A treatment for epilepsy is proposed based on analogues of 3-aminopropionic acid (β-alanine), a putative neurotransmitter in the central nervous system (CNS). A model three point pharmacophore was proposed based on modelling data obtained from the study of antagonists for both the glial γ-aminobutyric acid (GABA)-uptake site and the glycine co-agonist site of N-methyl-D-aspartate (NMDA) receptor. Three series of 3-aminopropionic acids containing, N-, α-, and β-substituents, were designed and synthesized to probe the position and the size of a lipophilic binding pocket within the proposed pharmacophore. These analogues were tested in vivo for both their antiseizure activities and their neurologic toxicities. Among the fourteen novel 3-aminopropionic acids synthesized, eight were found to have promising antiseizure activity. This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures.