3319-01-5 Usage
Description
1-Cyclohexylpiperidine is an organic compound with a cyclohexane ring and a piperidine ring, which is known for its various pharmacological properties and applications in the medical and chemical industries.
Uses
Used in Pharmaceutical Industry:
1-Cyclohexylpiperidine is used as a key intermediate in the synthesis of 1-(1-phenylcyclohexyl)piperidine, which exhibits anticholinesterase activity and antagonistic activity to acetylcholine. This makes it a valuable compound in the development of medications targeting neurological disorders.
Used in Neurological Applications:
1-Cyclohexylpiperidine is used as a N-methyl-D-aspartate receptor (NMDAR) antagonist, which plays a crucial role in modulating the excitatory neurotransmission in the central nervous system. Its antagonistic properties make it a potential candidate for the treatment of conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
Used in Veterinary Medicine:
1-Cyclohexylpiperidine is used as an anesthetic for animals, providing a safe and effective means of sedation and pain relief during medical procedures and surgeries. Its anesthetic properties make it a valuable asset in the veterinary field, ensuring the well-being and comfort of animals undergoing treatment.
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1597, 1950 DOI: 10.1021/ja01160a046Tetrahedron, 52, p. 10835, 1996 DOI: 10.1016/0040-4020(96)00631-X
Check Digit Verification of cas no
The CAS Registry Mumber 3319-01-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,1 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3319-01:
(6*3)+(5*3)+(4*1)+(3*9)+(2*0)+(1*1)=65
65 % 10 = 5
So 3319-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H21N/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h11H,1-10H2
3319-01-5Relevant articles and documents
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Bayles,Evans
, p. 6984,6985 (1965)
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Iridium and bis(4-nitrophenyl)phosphoric acid catalysed amination of diol by hydrogen-borrowing methodology for the synthesis of cyclic amine: Synthesis of clopidogrel
Swain, Sharada Prasanna,Shri, Om,Ravichandiran
, (2021/05/13)
The borrowing hydrogen method is an environmentally benign process for the synthesis of amines, as H2O is the side product. A new green process for the amination of diol by [Ir] catalyst 15 and bis(4-nitrophenyl)phosphoric acid for the synthesis of cyclic amine is reported. This method was successfully applied for the synthesis of antiplatelet drug clopidogrel.
Bidentate NHC-Cobalt Catalysts for the Hydrogenation of Hindered Alkenes
Wei, Zeyuan,Wang, Yujie,Li, Yibiao,Ferraccioli, Raffaella,Liu, Qiang
, p. 3082 - 3087 (2020/10/02)
Herein, we report a series of easily accessible bidentate N-heterocyclic carbene (NHC) cobalt catalysts, which enable the hydrogenation of hindered alkenes under mild conditions. The four-coordinated bidentate NHC-Co(II) complexes were characterized by X-ray diffraction, elemental analysis, ESI-HRMS, and magnetic moment measurements, revealing a distorted-tetrahedral geometry and a high-spin configuration of the metal center. The activity of the in situ formed catalytic system, which was obtained from easily available NHC precursors, CoCl2, and NaHBEt3, was identical with those of well-defined NHC-cobalt catalysts. This highlights the potential utility of this reaction system.
