33192-11-9

Basic information

• Product Name: Thiocyanic acid, 4-amino-2-methylphenyl ester
• CAS NO: 33192-11-9
• Molecular Formula: C8H8N2S
• Molecular Weight: 164.231
• Mol File: 33192-11-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Thiocyanic acid, 4-amino-2-methylphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thiocyanic acid, 4-amino-2-methylphenyl ester(33192-11-9)
• EPA Substance Registry System: Thiocyanic acid, 4-amino-2-methylphenyl ester(33192-11-9)

Safety Data

• Hazardous Substances Data: 33192-11-9(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 333-20-0 potassium thioacyanate 
• 598-49-2 N-chloroacetamide 
• 1147550-11-5 ammonium thiocyanate 
• 64-19-7 acetic acid 

Downstream Products

• 14030-88-7 2,6-dibromo-3-methyl-4-thiocyanato-aniline 
• 858847-02-6 2-bromo-5-methyl-4-thiocyanato-aniline 
• 84998-78-7 acetic acid-(3-methyl-4-thiocyanato-anilide) 
• 25924-77-0 bis-(4-amino-2-methyl-phenyl)-disulfide 
• 70611-05-1 4-amino-2-methylphenyl methyl sulphide 
• 23745-22-4 Cyclopropanecarboxylic acid (3-methyl-4-thiocyanato-phenyl)-amide 

Relevant articles and documents

Citric acid as a trifunctional organocatalyst for thiocyanation of aromatic and heteroaromatic compounds in aqueous media

A green and simple procedure for the thiocynation of aromatic and heteroaromatic rings in the presence of a catalytic amount of citric acid in water are described. The reactions proceed in high yields, with short reaction times and under mild conditions.

Rapid and efficient thiocyanation of phenols, indoles, and anilines in 1,1,1,3,3,3-hexafluoro-2-propanol under ultrasound irradiation

An efficient ultrasound-promoted thiocyanation of phenols, indoles, and anilines in the presence of N-chlorosuccinimide and NH4SCN using 1,1,1,3,3,3-hexafluoro-2-propanol as the solvent has been developed. The major features of the present protocol include the mild reaction conditions, short reaction times, good to excellent yields, and broad substrate scope. Moreover, scale-up synthesis can be achieved and the solvent can be easily recovered and reused.

Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN

A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosuccinimide (NCS) was found to be indispensable, and thiourea could greatly promote the reaction.