332-47-8

Basic information

• Product Name: 1-Bromo-4-(2-fluoroethoxy)benzene
• Synonyms: 1-Bromo-4-(2-fluoroethoxy)benzene
• CAS NO: 332-47-8
• Molecular Formula: C₈H₈BrFO
• Molecular Weight: 219.0509232
• Mol File: 332-47-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 248.7±20.0 °C(Predicted)
• Appearance: /
• Density: 1.445±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 1-Bromo-4-(2-fluoroethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-(2-fluoroethoxy)benzene(332-47-8)
• EPA Substance Registry System: 1-Bromo-4-(2-fluoroethoxy)benzene(332-47-8)

Safety Data

• Hazardous Substances Data: 332-47-8(Hazardous Substances Data)

Usage

General Description

1-bromo-4-(2-fluoroethoxy)benzene is a chemical compound with the molecular formula C8H8BrFO. It is a benzene derivative that contains a bromine atom and a 2-fluoroethoxy group attached to the benzene ring. 1-bromo-4-(2-fluoroethoxy)benzene is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It may also be used as a building block in organic synthesis and as a reagent in chemical research. Due to its potential for causing skin and eye irritation, as well as being harmful if swallowed, proper safety precautions should be taken when handling 1-bromo-4-(2-fluoroethoxy)benzene.

Upstream product

• 106-41-2 4-bromo-phenol 
• 762-49-2 2-fluoroethyl bromide 
• 383-50-6 2-fluoroethyl tosylate 

Downstream Products

• 1423135-38-9 {[4-(2-fluoroethoxy)phenyl]ethynyl}(trimethyl)silane 
• 864754-47-2 C₁₄H₂₀BFO₃ 

Relevant articles and documents

Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists

Excitotoxicity driven by overactivation of NMDA receptors represents a major mechanism of acute and chronic neurological and neurodegenerative disorders. Negative allosteric modulators interacting with the ifenprodil binding site of the NMDA receptor are able to interrupt this ongoing neurodamaging process. Starting from the potent 3-benzazepine-1,7-diol 4a novel NMDA receptor antagonists were designed by modification of the N-(4-phenylbutyl) side chain. With respect to developing novel fluorinated PET tracers, regioisomeric fluoroethoxy derivatives 11, 12, 14, and 15 were synthesized. Analogs 19 and 20 with various heteroaryl moieties at the end of the N-side chain were prepared by Sonogashira reaction and nucleophilic substitution. The fluoroethyl triazole 37 was obtained by 1,3-dipolar cycloaddition. In several new ligands, the flexibility of the (hetero)arylbutyl side chain was restricted by incorporation of a triple bond. The affinity towards the ifenprodil binding site was tested in an established competition assay using [3H]ifenprodil as radioligand. Introduction of a fluoroethoxy moiety at the terminal phenyl ring, replacement of the terminal phenyl ring by a heteroaryl ring and incorporation of a triple bond into the butyl spacer led to considerable reduction of GluN2B affinity. The phenol 15 (Ki = 193 nM) bearing a p-fluoroethoxy moiety at the terminal phenyl ring represents the most promising GluN2B ligand of this series of compounds. With exception of 15 showing moderate σ2 affinity (Ki = 79 nM), the interaction of synthesized 3-benzazepines towards the PCP binding site of the NMDA receptor, σ1 and σ2 receptors was rather low (Ki > 100 nM).

Pesticidal 2-fluoroethyl ethers

Pesticidal mono-, di-, and tri-2-fluoroethyl ethers of the formula R1 R2m Ar(OCH2 CH2 F)n, compositions thereof and their insecticidal, acaricidal and nematicidal uses are described and cla