332025-19-1

Basic information

• Product Name: Benzenesulfonamide, N-(4-iodophenyl)-4-nitro-
• CAS NO: 332025-19-1
• Molecular Formula: C12H9IN2O4S
• Molecular Weight: 404.185
• Mol File: 332025-19-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(4-iodophenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(4-iodophenyl)-4-nitro-(332025-19-1)
• EPA Substance Registry System: Benzenesulfonamide, N-(4-iodophenyl)-4-nitro-(332025-19-1)

Safety Data

• Hazardous Substances Data: 332025-19-1(Hazardous Substances Data)

Upstream product

• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 6965-75-9 4-amino-N-(4-iodophenyl)benzene-1-sulfonamide 
• 925459-68-3 4'-iodo-N-methyl-4-nitrobenzenesulfonanilide 

Relevant articles and documents

Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates

Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochemical generation of a hypervalent iodine mediator using an “ex-cell” approach, which avoids oxidative substrate decomposition. The more sustainable conditions give good to excellent yields in up to decagram scales.

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.

Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors

In order to create novel analgesic agents without gastric disturbance, structurally simple cyclooxygenase-1 (COX-1) inhibitors with a benzenesulfonanilide skeleton were designed and synthesized. As a result, compounds 11f and 15a, which possess a p-amino group on the benzenesulfonyl moiety and p-chloro group on the anilino moiety, showed COX-1-selective inhibition. Moreover compound 11f, which is the most potent compound in this study showed more potent analgesic activity than that of aspirin at 30 mg/kg by po. The anti-inflammatory activity and gastric damage, however, were very weak or not detectably different from aspirin. Since the structure of our COX-1 inhibitors are very simple, they may be useful as lead compounds for superior COX-1 inhibitors as analgesic agents without gastric disturbance.