332186-71-7

Basic information

• Product Name: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethoxy)carbonyl]oxy]-2,6-dimethylphenyl]-, methyl ester, (2E)-
• CAS NO: 332186-71-7
• Molecular Formula: C17H22O5
• Molecular Weight: 306.359
• Mol File: 332186-71-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethoxy)carbonyl]oxy]-2,6-dimethylphenyl]-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethoxy)carbonyl]oxy]-2,6-dimethylphenyl]-, methyl ester, (2E)-(332186-71-7)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-[[(1,1-dimethylethoxy)carbonyl]oxy]-2,6-dimethylphenyl]-, methyl ester, (2E)-(332186-71-7)

Safety Data

• Hazardous Substances Data: 332186-71-7(Hazardous Substances Data)

Upstream product

• 108-68-9 3,5-Dimethylphenol 
• 80826-86-4 4-iodo-3,5-dimethylphenol 

Downstream Products

• 332186-72-8 Methyl 3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoate 
• 779358-73-5 (3R)-3-methyl-3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acid 
• 779358-72-4 (3S)-3-methyl-3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acid 
• 779358-71-3 3-(4-tert-butoxycarbonyloxy-2,6-dimethyl-phenyl)-butyric acid 
• 779358-69-9 Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(E)-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propenyl]-phenyl ester 
• 779358-70-2 Carbonic acid tert-butyl ester 3,5-dimethyl-4-[(S)-1-methyl-3-oxo-3-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-propyl]-phenyl ester 
• 263239-05-0 3-(4-tert-Butoxycarbonyloxy-2,6-dimethylphenyl)propanoic acid 
• 332186-76-2 (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid 
• 332186-75-1 Boc-[(2S)-Mdp]-OH 
• 332186-73-9 (4S)-4-Benzyl-3-[3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoyl]-1,3-oxazolan-2-one 
• 378185-86-5 (2S)-1-[(4S)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)-2-methylpropan-1-one 
• 378185-95-6 (2S)-1-[(4S)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)-2-ethylpropan-1-one 

Relevant articles and documents

Stereospecific synthesis of (2S)-2-methyl-3-(2′,6′-dimethyl-4′-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide

To examine the effect of replacing the N-terminal amino group in opioid peptides with a methyl group on biological activity, a stereospecific synthesis of the tyrosine analogue (2S)-2-methyl-3-(2′,6′-dimethyl-4′-hydroxyphenyl)-propionic acid (Mdp) was performed. The enkephalin analogue (2S)-Mdp-D-Ala-Gly-Phe-Leu-NH2 turned out to be a quite potent δ opioid antagonist and a somewhat less potent μ antagonist, indicating that a positively charged N-terminal amino group is not a conditio sine qua non for the binding of opioid peptides to δ and μ receptors but may be required for signal transduction.