33288-79-8Relevant articles and documents
Azide-Dye Unexpected Bone Targeting for Near-Infrared Window II Osteoporosis Imaging
Zhang, Xiaoqing,Ji, Aiyan,Wang, Zhiming,Lou, Hongyue,Li, Jiafeng,Zheng, Lingling,Zhou, Yujing,Qu, Chunrong,Liu, Xingdang,Chen, Hao,Cheng, Zhen
, p. 11543 - 11553 (2021)
Azide is an important chemical functional group and has been widely used in chemical biology. However, the impact of azide on the in vivo behaviors of compounds has been rarely studied. Herein, azide was introduced into a fluorescent dye for the near-infr
Small molecule compound for selectively targeting waveform protein as well as preparation method and application of small molecule compound
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Paragraph 0073-0077, (2021/06/06)
The invention discloses a small molecule compound for selectively targeting waveform protein as well as a preparation method and application thereof, and the structural formula of the small molecule compound is shown as a formula (I) or a formula (II). Co
Magnesium tetrapyrazinoporphyrazines: Tuning of the pKa of red-fluorescent pH indicators
Karlikova, Martina,Cermakova, Veronika,Demuth, Jiri,Valer, Vojtech,Miletin, Miroslav,Novakova, Veronika,Zimcik, Petr
, p. 6162 - 6173 (2019/05/16)
Magnesium(ii) tetrapyrazinoporphyrazines (TPyzPzs) are excellent red fluorophores (λF ~ 663 nm, ΦF ~ 0.53 in THF). In this work, a series of magnesium(ii) complexes of unsymmetrical TPyzPzs bearing one or two phenol substituents was prepared. Suitable substitutions on the phenolic moiety tuned its pKa in the range of 5.5 to 13. Deprotonation of the phenolic group at higher pH induced a strong donor (phenolate) in the macrocycle that led to pH-dependent quenching of the red fluorescence of these indicators. pH sensing was proved in water solutions after the incorporation of TPyzPzs into two delivery systems-microemulsions and liposomes. The latter also serves as a simple model of biomembranes. Finally, a wavelength-ratiometric probe was constructed by the incorporation of a TPyzPz indicator and lipophilic pH-nonsensitive BODIPY dye into liposomes. Synthetic precursors for TPyzPzs, substituted pyrazine-2,3-dicarbonitriles, also represent donor-acceptor systems and the pH-dependent changes in absorption spectra may be easily visible to the naked eye.