333-07-3

Basic information

• Product Name: 6-Fluorohexanoic acid methyl ester
• Synonyms: 6-Fluorohexanoic acid methyl ester
• CAS NO: 333-07-3
• Molecular Formula: C7H13FO2
• Molecular Weight: 148.1753
• Mol File: 333-07-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 158.1°Cat760mmHg
• Flash Point: 48.7°C
• Appearance: /
• Density: 0.968g/cm³
• Vapor Pressure: 2.67mmHg at 25°C
• Refractive Index: 1.391
• CAS DataBase Reference: 6-Fluorohexanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluorohexanoic acid methyl ester(333-07-3)
• EPA Substance Registry System: 6-Fluorohexanoic acid methyl ester(333-07-3)

Safety Data

• Hazardous Substances Data: 333-07-3(Hazardous Substances Data)

Usage

Chemical compound

6-Fluorohexanoic acid methyl ester

Structure

Consists of a hexanoic acid backbone with a fluorine group attached at the sixth carbon and a methyl ester functional group

Physical properties

Colorless liquid with a pungent odor

Common use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Biological effects

Known for its ability to disrupt biological processes, used as a research tool in chemical and biological studies

Safety precautions

Handle with caution, may cause irritation to the skin, eyes, and respiratory system upon exposure

InChI:InChI=1/C7H13FO2/c1-10-7(9)5-3-2-4-6-8/h2-6H2,1H3

Upstream product

• 373-31-9 6-Fluorohexanenitrile 
• 14273-91-7 methyl 6-iodohexanoate 
• 108-94-1 cyclohexanone 

Downstream Products

• 373-05-7 6-fluoro hexanoic acid 

Relevant articles and documents

Efficient Synthesis of ω-[18F]Fluoroaliphatic Carboxylic Esters and Acids for Positron Emission Tomography

[18F]Fluoroaliphatic carboxylic acids are important PET tracers that have demonstrated a considerable potential to address the fatty acid oxidation-dependent processes in clinical patients. Herein, we report an efficient radiosynthetic approach to ω-[18F]fluoroaliphatic carboxylic esters and acids by nucleophilic radiofluorination of the readily available iodocarboxylic esters. Methyl 6-[18F]fluorohexanoate was further applied as a starting material for the preparation of the succinimide ester (NHS ester)-containing bifunctional radiofluorinated prosthetic group in two simple steps, 10 min each. The synthesized NHS ester of 6-[18F]fluorohexanoic acid can serve as an important reagent for a quick and efficient conjugation with peptides or proteins via amino groups of lysines.