33324-69-5

Basic information

• Product Name: N,N-Dimethyl-2-(3-trifluoromethyl-phenyl)-acetamide
• CAS NO: 33324-69-5
• Molecular Weight: 231.218
• Mol File: 33324-69-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-Dimethyl-2-(3-trifluoromethyl-phenyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Dimethyl-2-(3-trifluoromethyl-phenyl)-acetamide(33324-69-5)
• EPA Substance Registry System: N,N-Dimethyl-2-(3-trifluoromethyl-phenyl)-acetamide(33324-69-5)

Safety Data

• Hazardous Substances Data: 33324-69-5(Hazardous Substances Data)

Upstream product

• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 124-40-3 dimethyl amine 

Downstream Products

• 130198-52-6 1-[2-(dimethylamino)-1-(3-trifluoromethylphenyl)ethyl]cyclohexanol 

Relevant articles and documents

2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity

A series of 2-phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives was examined for the ability to inhibit both rat brain imipramine receptor binding and the synaptosomal uptake of norepinephrine (NE) and serotonin (5-HT). Neurotransmitter uptake inhibition was highest for a subset of 2-phenyl-2-(1-hydroxycyclohexyl)dimethylethylamines in which the aryl ring has a halogen or methoxy substituent at the 3- and/or 4-positions. Potential antidepressant activity in this subset was assayed in three rodent models - the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland. An acute effect seen in the rat pineal gland with several analogues, including 1-[1-(3,4-dichlorophenyl)-2-(dimethylamino)ethyl]cyclohexanol (23) and 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (4), was taken as a possible correlate of a rapid onset of antidepressant activity. Compound 4 (venlafaxine) is presently undergoing clinical evaluation.