333400-90-1

Basic information

• Product Name: 4-Quinazolinamine, 7-chloro-N-[2-(4-chlorophenyl)ethyl]-6-nitro-
• CAS NO: 333400-90-1
• Molecular Formula: C16H12Cl2N4O2
• Molecular Weight: 363.203
• Mol File: 333400-90-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Quinazolinamine, 7-chloro-N-[2-(4-chlorophenyl)ethyl]-6-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinazolinamine, 7-chloro-N-[2-(4-chlorophenyl)ethyl]-6-nitro-(333400-90-1)
• EPA Substance Registry System: 4-Quinazolinamine, 7-chloro-N-[2-(4-chlorophenyl)ethyl]-6-nitro-(333400-90-1)

Safety Data

• Hazardous Substances Data: 333400-90-1(Hazardous Substances Data)

Upstream product

• 5900-59-4 2-amino-4-chlorobenzamide 
• 31374-18-2 7-chloro-3,4-dihydroquinazolin-4-one 
• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 
• 156-41-2 4-chlorophenylethylamine 
• 162012-71-7 4,7-dichloro-6-nitro-quinazoline 

Downstream Products

• 333399-52-3 7-(4-aminomethylpiperidin-1-yl)-4-[2-(4-chlorophenyl)ethylamino]-6-nitroquinazoline 
• 333399-47-6 4-[2-(4-chlorophenyl)ethylamino]-7-(4-ethylpiperazin-1-yl)-6-nitroquinazoline 
• 333399-48-7 4-[2-(4-chlorophenyl)ethylamino]-7-[4-(2-hydroxyethyl)piperazin-1-yl)-6-nitroquinazoline 
• 333399-44-3 4-[2-(4-chlorophenyl)ethylamino]-6-nitro-7-(piperazin-1-yl)quinazoline 

Relevant articles and documents

Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

We disclose here a new structural class of low-molecular-weight inhibitors of NF-κB activation that were designed and synthesized by starting from quinazoline derivative 6a. Structure-activity relationship (SAR) studies based on 6a elucidated the structural requirements essential for the inhibitory activity toward NF-κB transcriptional activation, and led to the identification of the 6-amino-4-phenethylaminoquinazoline skeleton as the basic framework. In this series of compounds, 11q, containing the 4-phenoxyphenethyl moiety at the C(4)-position, showed strong inhibitory effects on both NF-κB transcriptional activation and TNF-α production. Furthermore, 11q exhibited an anti-inflammatory effect on carrageenin-induced paw edema in rats.