333744-42-6Relevant articles and documents
Copper-Catalyzed Difluoroalkylation-Thiolation of Alkenes Promoted by Na2S2O5
Gao, Bao,Ni, Yingjie,Liu, Xiaojun,Jiang, Tao,Yan, Qian,Yang, Ruiting,Zhang, Xiuli
, p. 1913 - 1918 (2021)
A novel and convenient protocol for the difluoroalkylation-thiolation of alkenes catalyzed by Cu/Na2S2O5 system has been developed. This reaction was carried out using readily available starting materials under mild conditions, wherein the C?C and C?S bonds simultaneously were constructed smoothly. The reaction features broad substrate scope of alkenes and disulfides, good functional group tolerance, and good to excellent yields with high selectivity.
Aryl Fluoroalkyl Sulfoxides: Optical Stability and pKa Measurement
Messara, Amélia,Vanthuyne, Nicolas,Diter, Patrick,Elhabiri, Mourad,Panossian, Armen,Hanquet, Gilles,Magnier, Emmanuel,Leroux, Frédéric R.
supporting information, p. 5019 - 5026 (2021/08/13)
The enantiomeric separation of aryl trifluoromethyl and difluoromethyl sulfoxides was realized via chiral chromatography. The configurational stability of each set of enantiomers was then studied by thermal enantiomerization. The ΔG≠ values obt
Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries
Batisse, Chloé,Panossian, Armen,Hanquet, Gilles,Leroux, Frédéric R.
supporting information, p. 10423 - 10426 (2018/09/21)
A new methodology to access enantiopure α,α-difluoromethyl alcohols is hereby being described. The strategy relies on the use of an enantiopure aryl α,α-difluoromethyl sulfoxide employed as chiral and removable auxiliary for the stereoselective difluoromethylation of carbonyl derivatives. The obtained α,α-difluoro-β-hydroxysulfoxides displayed unprecedented diastereomeric ratios.
