33376-96-4

Basic information

• Product Name: 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE
• Synonyms: 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE;TIMTEC-BB SBB010316;desdiethyltrapidil;5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine(SALTDATA: FREE);4-26-00-03733 (Beilstein Handbook Reference)
• CAS NO: 33376-96-4
• Molecular Formula: C6H7N5
• Molecular Weight: 149.15328
• Mol File: 33376-96-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.6g/cm³
• Refractive Index: 1.807
• PKA: 3.00±0.40(Predicted)
• CAS DataBase Reference: 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE(33376-96-4)
• EPA Substance Registry System: 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE(33376-96-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 33376-96-4(Hazardous Substances Data)

Usage

General Description

5-Methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine is a chemical compound with the formula C6H6N6. It belongs to the class of organic compounds known as 1,2,4-triazolo pyrimidines and is also classified as an aminopyrimidine. 5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE contains a triazolopyrimidine skeleton, which is a rare and unique structure in organic chemistry. It is used as a building block in the synthesis of pharmaceutical drugs and agrochemicals. The compound has potential applications in the pharmaceutical industry due to its unique structure and biological activity. Studies have shown that it can exhibit antiviral, antifungal, and anticancer properties, making it a valuable target for drug discovery and development.

InChI:InChI=1/C6H7N5/c1-4-2-5(7)11-6(10-4)8-3-9-11/h2-3H,7H2,1H3

Upstream product

• 24415-66-5 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine 
• 35523-67-2 4,7-dihydro-5-methyl-7-oxo[1,2,4]triazolo[1,5-a]pyrimidine 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 70807-22-6 3-hydroxycrotononitrile sodium salt 
• 2503-56-2 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol 

Relevant articles and documents

Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine ligand

We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)2] (1), [Zn(7-amtp)2(H2O)4](NO3)2·2(7-amtp)·6H2O (2) and [Zn(7-amtp)2(H2O)4](SO4)·1.5H2O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications.

1,2,4-Triazolopyrimidine; Reaktionen von Amino- und Hydrazino-1,2,4-triazolopyrimidine mit Dimethylformamid-dimethylacetal

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