333999-50-1

Basic information

• Product Name: (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline
• Synonyms: (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline
• CAS NO: 333999-50-1
• Molecular Weight: 480.585
• Mol File: 333999-50-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline(333999-50-1)
• EPA Substance Registry System: (S)-2-{(S)-1-[N-(4-methylphenyl)sulfonylamino]-2-(4-hydroxyphenyl)ethyl}-4-(4-methoxybenzyl)-2-oxazoline(333999-50-1)

Safety Data

• Hazardous Substances Data: 333999-50-1(Hazardous Substances Data)

Upstream product

• 4703-32-6 (S)-2-[N-(4-methylphenyl)sulfonylamino]-3-(4-hydroxyphenyl) propionic acid 
• 20989-19-9 (2S)-2-amino-3-(4-methoxyphenyl)propan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 113089-15-9 (S)-2-methoxycarbonylamino-3-(4-methoxyphenyl)-propionic acid methyl ester 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 60-18-4 L-tyrosine 
• 58559-09-4 Ethyl N-(p-tosyl)tyrosinate 
• 361520-05-0 (S)-2-[(methoxycarbonyl)amino]-3-(4-methoxyphenyl) propan-1-ol 

Downstream Products

• 333999-59-0 (1S,3S,6S,7S,8R,9R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-9-[(4-nitrophenyl)sulfonyloxy]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 
• 333999-60-3 (1S,3S,6S,7S,8S,9S)-7,9-diacetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 
• 361520-02-7 (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-2,2,2-trichloroethoxycarbonyl-N-methyl-amino]-1-azaspiro[4.5]decane-8-ol 
• 331665-37-3 (1S,3S,6S,7S,8S,9R)-7-acetoxy-9-hydroxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4-one 
• 333999-62-5 (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol 
• 361520-03-8 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-8-oxo-1-aza-spiro[4.5]dec-3-yl)-N-methyl-acetamide 
• 361520-01-6 (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-amino]-1-azaspiro[4.5]decane-8-ol 
• 333999-61-4 (1S,3S,6S,7S,8S,9S)-6-(4-methoxybenzyl)-3-(N-methylamino)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol 
• 361519-96-2 (2S,5S,6S,7S,8R,10aS)-octahydro-5-[(4-methoxyphenyl)methyl]-2-methylamino-1H-7,10a-methanopyrrolo[1,2-a]azocine-6,8-diol 
• 361520-00-5 (3S,1S')-1-{2'-hydroxy-1'-[4-(3-methyl-but-2-enyloxy)benzyl]-ethyl}-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-1-azaspiro[4.5]decan-2,8-dione 
• 333999-58-9 (1S,3S,6S,7S,8R)-7-acetoxy-6-(4-methoxybenzyl)-3-[N-methyl-N-(4-methylphenyl)sulfonylamino]-5-azatricyclo[6.3.1.0^1,5]dodecan-4,9-dione 
• 361520-04-9 (3S,1S')-1-{1'-formyl-2'-[4-(3-methyl-but-2-enyloxy)phenyl]-ethyl}-3-[N-2,2,2-trichloroethoxycarbonyl-N-methyl-amino]-1-azaspiro[4.5]decan-8-one 

Relevant articles and documents

Total synthesis of FR901483

The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect th

Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

A solution to the long-standing problem presented by the oxidative cyclization of a phenolic 3-arylpropionamide to a spirolactam has been developed in this laboratory via oxazoline chemistry. This research was motivated by our interest in some novel tricyclic azaspirane natural products formally derived from tyrosine, such as FR901483 and TAN1251C. In this paper, we disclose full details of the total synthesis of these substances.