334010-50-3

Basic information

• Product Name: 2-chloro-4-(phenylthio)pyridine
• Synonyms: 2-chloro-4-(phenylthio)pyridine
• CAS NO: 334010-50-3
• Molecular Weight: 221.71
• Mol File: 334010-50-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(phenylthio)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(phenylthio)pyridine(334010-50-3)
• EPA Substance Registry System: 2-chloro-4-(phenylthio)pyridine(334010-50-3)

Safety Data

• Hazardous Substances Data: 334010-50-3(Hazardous Substances Data)

Upstream product

• 23056-36-2 2-chloro-4-nitropyridine 
• 108-98-5 thiophenol 

Downstream Products

• 607723-81-9 2-[methyl[4-(phenylthio)pyridin-2-yl]amino]ethanol 
• 607723-99-9 4-[2-[methyl[4-(phenylthio)pyridin-2-yl]amino]ethoxy]benzaldehyde 

Relevant articles and documents

Stabilised 2,3-pyridyne reactive intermediates of exceptional dienophilicity

The enhanced dienophilicity of 4-methoxy, 4-aryloxy and 4-thiophenoxy analogues 6-9 of 2,3-pyridyne (2) relative to 2 itself is reported. The regioselective lithiation of 4-alkoxy-(22, 23 and 25) and 4-thiophenoxy-2- chloropyridme (24) at low temperatures, followed by elimination of lithium chloride affords 4-alkoxy- and 4-thiophenoxypyridynes, which can be trapped in situ in a [4+2] cycloaddition reaction with furan to give endoxides 28-31 in moderate to good yields (25-58%). In contrast, precursors with a hydrogen (18) or methyl (12) substituent at C-4 give no evidence for pyridyne formation under these conditions. Attempts to generate 6-isopropoxy-2,3-pyridyne (10) from the low-temperature lithiation of 2-chloro-6-isopropoxypyridine were unsuccessful due to the instability of the 2-chloro-6-isopropoxy-5-lithiopyridine. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their biological activities, 5-(4-{2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy} benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.