33403-02-0

Basic information

• Product Name: 7-methyl-3,7-dihydro-1H-purine-2,6-dithione
• CAS NO: 33403-02-0
• Molecular Formula: C₆H₆N₄S₂
• Molecular Weight: 198.2686
• Mol File: 33403-02-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 446.5°C at 760 mmHg
• Flash Point: 223.8°C
• Density: 1.74g/cm³
• Vapor Pressure: 3.64E-08mmHg at 25°C
• Refractive Index: 1.896
• CAS DataBase Reference: 7-methyl-3,7-dihydro-1H-purine-2,6-dithione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methyl-3,7-dihydro-1H-purine-2,6-dithione(33403-02-0)
• EPA Substance Registry System: 7-methyl-3,7-dihydro-1H-purine-2,6-dithione(33403-02-0)

Safety Data

• Hazardous Substances Data: 33403-02-0(Hazardous Substances Data)

Upstream product

• 2273-93-0 2,6-dichloro-7-methylpurine 
• 17356-08-0 thiourea 
• 110-89-4 piperidine 
• 53050-28-5 2-chloro-7-methyl-6-purinethione 
• 110-91-8 morpholine 
• 83-67-0 theobromine / 
• 552-62-5 7-methylxanthine 
• 933443-18-6 6-chloro-7-methyl-2-thioxo-2,3-dihydropurine 
• 1411565-08-6 2,6-bis(2-diethylaminoethylthio)-7-methylpurine 
• 1411565-12-2 2,6-bis(3-dimethylaminopropylthio)-7-methylpurine 

Relevant articles and documents

Synthesis of 2- and 6-(dialkylaminoalkylthio)- and 2,6- bis(dialkylaminoalkylthio)-7-methylpurines

An efficient synthesis of 21 new thiopurines being 2-substituted 6-(dialkylaminoalkylthio)-7-methylpurines, 6-substituted 2- (dialkylaminoalkylthio)- 7-methylpurines, and 2,6-bis(dialkylaminoalkylthio)-7- methylpurines was reported. 2-Substituted 6-(dialkylaminoalkylthio) and 2,6-bis(dialkylaminoalkylthio) derivatives were obtained via direct S-dialkylaminoalkylation of the appro- priate purinethiones. The different reactivities of the dialkylaminalkylthio groups in positions 2 and 6 towards sodium alkoxides were the key processes in a few step synthesis of 2-(dialkylaminoalkylthio) derivatives from 2,6-bis(dialkylaminoalkylthio) derivatives.

Products of the reaction of 2-chloro-6-thio-7-methylpurine with amines

Treatment of 2-chloro-6-thio-7-methylpurine with aniline, piperidine, or morpholine with heating in DMF gives 2-phenylamino(piperidino or morpholino)-6-thio-7-methylpurine. The scheme for the formation of the side products 2.6-dithio- and 2,6-dipiperidino-7-methylpurine is discussed.