33421-20-4Relevant articles and documents
A solution to the 2-pyridyl organometallic cross-coupling problem: Regioselective catalytic direct arylation of pyridine N-oxides
Campeau, Louis-Charles,Rousseaux, Sophie,Fagnou, Keith
, p. 18020 - 18021 (2005)
Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions. Copyright
Substitution of the nitro group with Grignard reagents: Facile arylation and alkenylation of pyridine N-oxides
Zhang, Fang,Zhang, Song,Duan, Xin-Fang
, p. 5618 - 5620 (2013/01/15)
The unprecedented substitution of a nitro group with aryl or alkenyl groups of Grignard reagents affords 2-aryl or alkenylpyridine N-oxides in modest to high yields with high chemoselectivity. This protocol allows a simple and clean synthesis of various 2
Use of N-oxide compounds in coupling reactions
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Page/Page column 7-8, (2008/12/05)
Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3
