334658-24-1

Basic information

• Product Name: BODIPY CYCLOPAMINE
• Synonyms: BODIPY CYCLOPAMINE;[5-[(3,5-DiMethyl-2H-pyrrol-2-ylidene-κN)Methyl]-N-[6-[[2-[(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetraMethylspiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]aMino]-6-oxohexyl]-1H-pyrrole-2-propanaMidato-κN1]difluoro-boron
• CAS NO: 334658-24-1
• Molecular Formula: C49H70BF2N5O4
• Molecular Weight: 841.9190064
• Product Categories: Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;Inhibitors;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorescent Labels & Indicators, Inhibitors, Steroids, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 334658-24-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 128-130°C
• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: BODIPY CYCLOPAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: BODIPY CYCLOPAMINE(334658-24-1)
• EPA Substance Registry System: BODIPY CYCLOPAMINE(334658-24-1)

Safety Data

• Hazardous Substances Data: 334658-24-1(Hazardous Substances Data)

Usage

Description

BODIPY CYCLOPAMINE, also known as Bodipy-Cyclopamine, is a fluorescent derivative of Cyclopamine, a naturally occurring steroidal alkaloid. It possesses teratogenic properties and has been shown to reverse the effects of oncogenic mutations in Smoothened and Patched. BODIPY CYCLOPAMINE retains its potency in Shh signaling inhibition, making it a valuable tool in various applications.

Uses

Used in Pharmaceutical Industry:
BODIPY CYCLOPAMINE is used as a research tool for studying the Hedgehog signaling pathway, which plays a crucial role in embryonic development and is implicated in various cancers. Its ability to inhibit Shh signaling makes it a potential therapeutic agent for cancer treatment.
Used in Biomedical Research:
BODIPY CYCLOPAMINE is used as a fluorescent probe for visualizing cellular processes and monitoring the activity of the Hedgehog signaling pathway in living cells. Its fluorescent properties allow researchers to track the compound's distribution and interaction with cellular components, providing valuable insights into the molecular mechanisms underlying Hedgehog signaling.
Used in Drug Development:
BODIPY CYCLOPAMINE is used as a lead compound in the development of new drugs targeting the Hedgehog signaling pathway. Its potent inhibition of Shh signaling and teratogenic properties make it a promising candidate for further optimization and development into a therapeutic agent for cancer and other diseases associated with aberrant Hedgehog signaling.
Chemical Properties:
BODIPY CYCLOPAMINE is an orange powder, which indicates its solid state and the presence of conjugated systems in its molecular structure, contributing to its fluorescent properties.