3347-62-4

Basic information

• Product Name: 3-METHYL-5-PHENYL-1H-PYRAZOLE
• Synonyms: 1H-Pyrazole, 3-methyl-5-phenyl-;3-methyl-5-phenyl-1h-pyrazol;5-Methyl-3-phenylpyrazole;Femerazol;Phemerazole;Pyrazole, 3-methyl-5-phenyl-;SALOR-INT L496162-1EA;3-METHYL-5-PHENYL-1H-PYRAZOLE
• CAS NO: 3347-62-4
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• EINECS: 222-099-1
• Product Categories: organic amine
• Mol File: 3347-62-4.mol
• Article Data: 45

Chemical Properties

• Melting Point: 126-127°C
• Boiling Point: 333.9°Cat760mmHg
• Flash Point: 156.2°C
• Appearance: pale yellow/solid
• Density: 1.109g/cm³
• Vapor Pressure: 0.000258mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.08±0.10(Predicted)
• CAS DataBase Reference: 3-METHYL-5-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-5-PHENYL-1H-PYRAZOLE(3347-62-4)
• EPA Substance Registry System: 3-METHYL-5-PHENYL-1H-PYRAZOLE(3347-62-4)

Safety Data

• Hazard Codes: Xi
• Statements: Xi:刺激性物质
• RTECS: UQ7525000
• HazardClass: IRRITANT
• Hazardous Substances Data: 3347-62-4(Hazardous Substances Data)

Usage

General Description

3-METHYL-5-PHENYL-1H-PYRAZOLE is a chemical compound with the molecular formula C11H10N2. It is a pyrazole derivative, which is a five-membered heterocyclic compound containing three carbon atoms and two nitrogen atoms in the ring. 3-METHYL-5-PHENYL-1H-PYRAZOLE is used in the synthesis of pharmaceuticals and other organic compounds. It exhibits biological activity and is commonly used as a building block in the development of various drugs and agrochemicals. Its unique structure and properties make it a valuable tool in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C10H10N2/c1-8-7-10(12-11-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)

Upstream product

• 110-91-8 morpholine 
• 79815-53-5 anhydro-2,5-diphenyl-1-hydroxy-7-methyl-3-oxopyrazolo<1,2-a>pyrazolium hydroxide 
• 77202-05-2 1-amino-5-methyl-3-phenylpyrazole 
• 90861-40-8 acetone 3-imino-1-methyl-phenylprop-1-enylhydrazone 
• 82755-33-7 3-Methyl-5-phenyl-3,4-dihydro-2H-pyrazol-3-ol 
• 94012-56-3 3-phenyl-5-(phenylsulfonylmethyl)pyrazole 
• 93-91-4 1-phenylbutan-1,3-dione 
• 10222-79-4 3-phenyl-5-methylpyrazole-1-carboxamide 
• 23652-90-6 (2Z)-3-amino-1-phenylbut-2-en-1-one 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 126-98-7 methacrylonitrile 
• 94012-44-9 3-methylthio-1-phenyl-4-phenylsulfonyl-2-buten-1-one 
• 98-86-2 acetophenone 

Downstream Products

• 13808-66-7 4-bromo-3-methyl-5-phenyl-1H-pyrazole 
• 92670-68-3 2-<1-(5-methyl-3-phenylpyrazolyl)>-1,4-diphenylbut-2-ene-1,4-dione 
• 77202-10-9 4-methyl-6-phenyl-1,2,3-triazine 
• 77202-05-2 1-amino-5-methyl-3-phenylpyrazole 
• 99214-42-3 1-amino-3-methyl-5-phenylpyrazole 
• 84691-22-5 4,4-Dibromo-3-methyl-5-phenyl-4H-pyrazole 
• 160730-46-1 (6aR,9R,10aR)-7-Methyl-9-(3-methyl-5-phenyl-pyrazol-1-ylmethyl)-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline 
• 115219-09-5 (6aR,9R,10aR)-7-Methyl-9-(5-methyl-3-phenyl-pyrazol-1-ylmethyl)-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline 
• 115219-09-5 (6aR,9S,10aR)-7-Methyl-9-(5-methyl-3-phenyl-pyrazol-1-ylmethyl)-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline 
• 91-20-3 naphthalene 
• 622-76-4 1-phenyl-1-butyne 
• 767-59-9 1-Methylinden 
• 767-60-2 3-Methylindene 
• 1515-78-2 buta-1,3-dien-1-ylbenzene 

Relevant articles and documents

Regiocontrolled Coupling of Alkynes and Dipolar Reagents: Iron-Mediated [3 + 2] Cycloadditions Revisited

Cyclopentadienyliron dicarbonyl based allenyliron complexes were prepared, and their formal [3 + 2] cycloaddition with a number of dipolar reagents was investigated as a means of preparing heterocyclic compounds in a regiocontrolled manner. In addition, the mechanism of the isomerization of an allenyliron complex to its propargyliron tautomer was investigated. Results in support of both radical and two-electron mechanisms for isomerization are presented.

Identification of potent anticancer copper(ii) complexes containing tripodal bis[2-ethyl-di(3,5-dialkyl-1H-pyrazol-1-yl)]amine moiety

A series of heteroleptic copper(ii) complexes of the composition [Cu(L1-5)Cl]X, where X = ClO4 and/or PF6 and [bis(2-ethyl-di(3,5-dimethyl-1H-pyrazol-1-yl))-(6-methyl-(2-pyridylmethyl))]amine (L1), [bis(2-ethyl-di(3,5-dimethyl-1H-pyrazol-1-yl))-(3,4-dimethoxy-(2-pyridylmethyl))]amine (L2), [bis(2-ethyl-di(3,5-dimethyl-1H-pyrazol-1-yl)-(2-quinolymethyl)]amine (L3), [bis(2-ethyl-di(3,5-dimethyl-1H-pyrazolyl)-(di(3,5-dimethyl-1H-pyrazol-1-yl-methyl))]amine (L4) and [bis(2-ethyl-di(3,5-dimethyl-1H-pyrazol-1-yl)-(5-methyl-3-phenyl-1H-pyrazol-1-yl-methyl)]amine (L5), were prepared and thoroughly characterized including single-crystal X-ray diffraction technique. The in vitro cytotoxicity of complexes against A2780, A2780R, HOS and MCF-7 human cancer cell lines was evaluated using the MTT test. The results revealed that complexes [Cu(L1)Cl]PF6 (1-PF6), [Cu(L2)Cl]ClO4 (2-ClO4) and [Cu(L3)Cl]PF6 (3-PF6) are the most effective, with IC50 values ranging from 1.4 to 6.3 μM, thus exceeding the cytotoxic potential of metallodrug cisplatin (IC50 values ranging from 29.9 to 82.0 μM). The complexes [Cu(L4)Cl]PF6 (4-PF6) and [Cu(L5)Cl]PF6 (5-PF6) showed only moderate cytotoxicity against A2780, with IC50 = 53.6 μM, and 33.8 μM, respectively. The cell cycle profile, time-resolved cellular uptake, interactions with small sulfur-containing biomolecules (cysteine and glutathione), intracellular ROS production, induction of apoptosis and activation of caspases 3/7 were also evaluated in the case of the selected complexes. It has been found that the best performing complexes 1 and 2 cause cell arrest in the G2/M phase and induce apoptosis via the increase in production of ROS, dominantly due to the overproduction of superoxide.

Cs2CO3-promoted P-N coupling reaction of H-phosphoryl compounds with N-tosylhydrazones to afford N-phosphorylhydrazones via diazo intermediates

The Cs2CO3-promoted P-N coupling reaction of H-phosphoryl compounds and N-tosylhydrazones is reported. Formally, this transformation represents an interesting example of exchanging the sulfur and phosphorus functionalities to convert