334701-04-1

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 7-(acetyloxy)-2-[4-(acetyloxy)phenyl]-2,3-dihydro-5-hydroxy-8-(3-methyl- 2-butenyl)-
• CAS NO: 334701-04-1
• Molecular Formula: C24H24O7
• Molecular Weight: 424.45
• Mol File: 334701-04-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 7-(acetyloxy)-2-[4-(acetyloxy)phenyl]-2,3-dihydro-5-hydroxy-8-(3-methyl- 2-butenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 7-(acetyloxy)-2-[4-(acetyloxy)phenyl]-2,3-dihydro-5-hydroxy-8-(3-methyl- 2-butenyl)-(334701-04-1)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 7-(acetyloxy)-2-[4-(acetyloxy)phenyl]-2,3-dihydro-5-hydroxy-8-(3-methyl- 2-butenyl)-(334701-04-1)

Safety Data

• Hazardous Substances Data: 334701-04-1(Hazardous Substances Data)

Upstream product

• 3162-03-6 2-(4-acetoxyphenyl)-5-hydroxy-4-oxochroman-7-yl acetate 
• 480-41-1 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on 
• 334701-03-0 4-(7-acetoxy-5-((3-methylbut-2-en-1-yl)oxy)-4-oxochroman-2-yl)phenyl acetate 

Downstream Products

• 68682-02-0 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but-2-enyl)-chroman-4-one 
• 569-83-5 xanthohumol 
• 521-48-2 isoxanthohumol 
• 53846-50-7 sophoraflavanone B 

Relevant articles and documents

Molecular docking and panicolytic effect of 8-prenylnaringenin in the elevated T-maze

The purpose of this study was to investigate the effects of the chronic administration of a racemic mixture of 8-prenylnaringenin (8-PN) on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders. The selective serotonin (SERT) reuptake inhibitor fluoxetine was used as a positive control. Rat locomotion was assessed in a circular arena following each drug treatment. The administration of racemic 8-PN for 21 d in rats increased one-way escape latencies from the ETM open arm, indicating a panicolytic effect. To evaluate the interactions of 8-PN with monoamine transporters, a docking study was performed for both the R and S configurations of 8-PN towards SERT, norepinephrine (NET) and dopamine transporters (DAT). The application of the docking protocol showed that (R)-8-PN provides greater affinity to all transporters than does the S enantiomer. This result suggests that enantiomer (R)-8-PN is the active form in the in vivo test of the racemic mixture.

Use of 8-Prenylnaringenin for hormone replacement therapy

The invention provides a production method for the phytoestrogen 8-Prenylnaringenin, the preparation produced by this method and the use of 8-Prenylnaringenin for the production of a medicament for the prevention and treatment of hormone-dependent osteopo