334792-87-9

Basic information

• Product Name: Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate
• Synonyms: Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate
• CAS NO: 334792-87-9
• Molecular Weight: 301.265
• Mol File: 334792-87-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate(334792-87-9)
• EPA Substance Registry System: Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate(334792-87-9)

Safety Data

• Hazardous Substances Data: 334792-87-9(Hazardous Substances Data)

Upstream product

• 22227-63-0 methyl 3-nitro-5-(trifluoromethyl)-benzoate 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 3592-25-4 1,5-dichloropentan-3-one 
• 22235-25-2 3-amino-5-trifluoromethylbenzoic acid methyl ester 

Downstream Products

• 334792-94-8 tert-butyl (2S)-benzenesulfonylamino-3-[3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoylamino]propionate 
• 334792-95-9 (2S)-benzenesulfonylamino-3-[3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoylamino]propionic acid 
• 334792-93-7 3-(4-(pyrimidin-2-ylamino)piperidin-1-yl)-5-(trifluoromethyl)benzoic acid 
• 334792-92-6 methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate 
• 334792-89-1 methyl 3-{4-(methanesulfonyloxy)-piperidin-1-yl}-5-(trifluoromethyl)benzoate 
• 334792-90-4 methyl 3-(4-azidopiperidin-1-yl)-5-(trifluoromethyl)benzoate 
• 334792-91-5 methyl 3-(4-aminopiperidin-1-yl)-5-(trifluoromethyl)benzoate 
• 334792-88-0 methyl 3-(4-hydroxypiperidin-1-yl)-5-(trifluoromethyl)benzoate 

Relevant articles and documents

Fluorescent non-peptidic RGD mimetics with high selectivity for αvβ3 vs αiIbβ3 integrin receptor: Novel probes for in vivo optical imaging

Integrins are heterodimeric transmembrane protein receptors consisting of different α and β subunits. αvβ3 integrins are overexpressed on many tumor cells and tumor-associated angiogenic vessels, whereas αIIbβ3 is a receptor for, e.g., fibrinogen and mediates platelet aggregation. In this study, a near-infrared fluorescent imaging probe has been designed and synthesized by conjugating fluorescent dyes to a non-peptidic, pharmacophore-based ligand, based on a molecular modeling design approach. Affinity values were determined, and in vitro cell binding assays and preliminary in vivo xenograft studies in nude mice were performed to evaluate target binding. Competition assays revealed excellent binding and selectivity to αvβ3 compared to that for αIIbβ3. In vitro, the probe showed high target binding on αvβ3-positive M-21 cells and negligible binding to αvβ3-negative MCF-7 cells. In vivo, the tracer is able to image target expression in U-87 xenografts with a maximum signal-to-noise ratio (SNR) of 2.5:1 at 24 h after injection.

m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM

An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin αvβ3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; X represents CH or N; R7 and R8 represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10 represents optionally substituted hydroxyl, amino or the like; R11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.