33488-35-6

Basic information

• Product Name: 2(1H)-Quinoxalinone, 6-chloro-3-phenyl-
• CAS NO: 33488-35-6
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 33488-35-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2(1H)-Quinoxalinone, 6-chloro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone, 6-chloro-3-phenyl-(33488-35-6)
• EPA Substance Registry System: 2(1H)-Quinoxalinone, 6-chloro-3-phenyl-(33488-35-6)

Safety Data

• Hazardous Substances Data: 33488-35-6(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 62-53-3 aniline 
• 2427-71-6 6-chloro-1,2-dihydroquinoxalin-2-one 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 424799-86-0 4-chloro-2-nitro-N-(2-phenylethen-1-yl)benzenamine 
• 536-74-3 phenylacetylene 

Downstream Products

• 76672-25-8 2,6-Dichloro-3-phenylquinoxaline 

Relevant articles and documents

Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines

A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.

Visible-light-induced, copper(i)-catalysed C-N coupling between o-phenylenediamine and terminal alkynes: One-pot synthesis of 3-phenyl-2-hydroxy-quinoxalines

Visible-light-initiated aerobic direct C-N coupling between o-phenylenediamines and terminal acetylenes was performed using simple copper(i) chloride as a catalyst for the synthesis of quinoxaline derivatives. The current method works well for a wide range of electron rich as well as electron poor group-substituted o-phenylenediamines and phenylacetylenes. The key component in the reaction is the direct photo-excitation of in situ generated copper arylacetylide (λabs = 420-480 nm). Moreover, as compared to the literature reports (thermal process), the current photochemical method is simple, mild, high yielding, and more viable towards the construction of biologically important quinoxaline derivatives from easily accessible raw materials, without the need of ligands and strong oxidants.

Potential virostatics. 1. Quinoxalines

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