334990-98-6

Basic information

• Product Name: 2-[4'-(2-pyridyl)phenyl]-5,5-dimethyl-1,3-dioxane
• Synonyms: 2-[4'-(2-pyridyl)phenyl]-5,5-dimethyl-1,3-dioxane
• CAS NO: 334990-98-6
• Molecular Weight: 269.343
• Mol File: 334990-98-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4'-(2-pyridyl)phenyl]-5,5-dimethyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4'-(2-pyridyl)phenyl]-5,5-dimethyl-1,3-dioxane(334990-98-6)
• EPA Substance Registry System: 2-[4'-(2-pyridyl)phenyl]-5,5-dimethyl-1,3-dioxane(334990-98-6)

Safety Data

• Hazardous Substances Data: 334990-98-6(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 105114-53-2 1-bromo-4-(5,5-dimethyl-1,3-dioxan-2-yl)benzene 

Downstream Products

• 127406-56-8 4-(2'-pyridyl)benzaldehyde 

Relevant articles and documents

Process for the preparation of aryl-pyridinyl compounds

A process is described for the preparation of arylpyridine compounds by aryl-aryl cross-coupling reactions between a halopyridine and an arylmagnesium halide carried out in the presence of a catalytic amount of a zinc salt and a catalytic amount of palladium. The zinc salt is preferably selected from ZnCl2, ZnBr2 and/or Zn(OAc)2, while the palladium is preferably used in the form of Pd(PPh3)4 or Pd(OAc)2 +4 PPh3. The reaction can also be carried out in the presence of bidentate phosphines, such as, for example, 1,3-bis(diphenylphosphine)propane or 1,4-bis(diphenylphosphine)-butane. It is thus possible to obtain molar yields higher than 97% (calculated relative to the halopyridine) and a catalyticity of more than 2000.