335-57-9 Usage
Description
Hexadecafluoroheptane, also known as Perfluoroheptane, is a common liquid perfluoro-n-alkane that serves as a fluorinated solvent. It is characterized by its clear light yellow appearance and is known for its unique physical properties, making it suitable for various applications across different industries.
Uses
1. Used in Chemical Research:
Hexadecafluoroheptane is used as a solvent in solution-phase studies of perfluoropolyalkylene oligomers. Its fluorinated nature allows for the efficient study and synthesis of these complex molecules.
2. Used in Pharmaceutical Industry:
Hexadecafluoroheptane is used as a component in the preparation of fluorinated gel emulsions. These emulsions have potential applications in the pharmaceutical industry, particularly in drug delivery systems and the development of novel treatments.
3. Used in Material Science:
The aggregation of diblock semifluorinated in perfluoroheptane has been reported, indicating its potential use in material science for the development of new materials with unique properties.
4. Used in Commercial and Industrial Applications:
Hexadecafluoroheptane's physical properties and its status as a fluorinated solvent make it suitable for various commercial and industrial uses, although specific applications are not detailed in the provided materials.
Safety Profile
Low toxicity by intraperitoneal route. Poison by intraperitoneal route. When heated to decomposition it emits very toxic fumes such as Fí.
Purification Methods
Purify it as for perfluorodimethylhexane. Other procedures include shaking with H2SO4, washing with water, drying with P2O5 for 48hours and fractionally distilling. Alternatively, it has been refluxed for 24hours with saturated acid KMnO4 (to oxidise and remove hydrocarbons), then neutralised, steam distilled, dried with P2O5, and passed slowly through a column of dry silica gel. It has been purified by fractional crystallisation using partial freezing. [Beilstein 1 IV 388.]
Check Digit Verification of cas no
The CAS Registry Mumber 335-57-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 335-57:
(5*3)+(4*3)+(3*5)+(2*5)+(1*7)=59
59 % 10 = 9
So 335-57-9 is a valid CAS Registry Number.
InChI:InChI=1/C7F16/c8-1(9,2(10,11)4(14,15)6(18,19)20)3(12,13)5(16,17)7(21,22)23
335-57-9Relevant articles and documents
Yield improvement in the electrochemical production of pefluorooctanoic acid
Napoli, M.,Scipioni, A.,Gambaretto, G. P.,Carlini, F. M.,Bertola, M.
, p. 261 - 264 (1994)
The possibility of obtaining real yield improvements in the industrial electrochemical production of perfluorooctanoic acid is discussed on the basis of recent experimental data obtained using perfluorohexyl acetyl chloride in place of octanoyl chloride as a starting material.In particular, the effect of the non-formation of cyclic byproducts on the yield of perfluoro-octanoic acid has been examined, as well as considering previous results obtained starting from a different partially fluorinated precursor, 4-perfluorobutyl butanoyl chloride.The yield of perfluoro-octanoic acid from perfluorohexyl acetyl chloride was less than expected, because of an accompanying increase in perfluoro-n-heptane formation.
Dresdner
, p. 6633 (1955)
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Benner et al.
, p. 329,332 (1947)
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THE SYNTHESIS OF PERFLUORO HIGHLY BRANCHED HETEROCYCLIC FLUORINE COMPOUNDS BY DIREKT FLUORINATION
Lin, Wen-Huey,Lagow, Richard J.
, p. 15 - 30 (2007/10/02)
The direct fluorination of hexamethyleneimine, heptamethyleneimine, 2,6-dimethylmorpholine, thiomorpholine, 1,4-dimethylpiperazine and piperazine produced the corresponding perfluoinated products.The 19F NMR spectrum of perfluoro N,N'-difluoropiperazine was found to be temperature-dependent.
ANALYSIS OF THE PRODUCTS FROM THE ELECTROCHEMICAL FLUORINATION OF OCTANOYL CHLORIDE
Prokop, H.W.,Zhou, H-J,Xu, S-Q,Wu, C-H,Liu, C. C.
, p. 277 - 290 (2007/10/02)
The perfluorinated products from the electrochemical fluorination of octanoyl chloride were analyzed using several techniques.Cappillary gas chromatography was used for quantitative analysis of the desired product, perfluorooctanoyl fluoride, and for perfluorinated cyclic ether by-products.Isopropyl ether was an effective solvent, and ethylbenzene served as an internal standard.Acidimetric titration was used to qualify the amount of acid derivative products present in the sample.Since the products have limited solubility in water, alternative solvents were developed.Taking advantage of the facile hydrolysis of the acyl fluoride product, the perfluorinated acid was isolated.Details of the application of these chemical techniques to perfluorinated products and the corresponding results will be discussed.
