33507-93-6

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 5,6-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-7-hydroxy-
• CAS NO: 33507-93-6
• Molecular Formula: C21H16O9
• Molecular Weight: 412.353
• Mol File: 33507-93-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 5,6-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-7-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 5,6-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-7-hydroxy-(33507-93-6)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 5,6-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-7-hydroxy-(33507-93-6)

Safety Data

• Hazardous Substances Data: 33507-93-6(Hazardous Substances Data)

Upstream product

• 1168-42-9 5,6,7,4'-tetramethoxyflavone 
• 3877-67-6 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 642-71-7 3,4,5-trimethoxyphenol 
• 33507-92-5 7-(benzyloxy)-5,6-diacetoxy-2-(4-acetoxyphenyl)-4H-chromen-4-one 
• 1180-46-7 4,5,6,7-tetra-O-acetylflavone 
• 529-53-3 scutellarein 
• 27740-01-8 scutellarin 

Downstream Products

• 26046-94-6 plantaginin 
• 676536-34-8 scutellarein 7-O-glucuronopyranoside 
• 29528-35-6 7-methoxy-5,6-diacetoxy-2-(4'-acetoxyphenyl)-4H-1-benzopyran-4-one 
• 23130-22-5 5,6-dihydroxy-2-(4-hydroxy-phenyl)-7-methoxy-chromen-4-one 
• 33507-92-5 7-(benzyloxy)-5,6-diacetoxy-2-(4-acetoxyphenyl)-4H-chromen-4-one 

Relevant articles and documents

Synthesis and biological evaluation of scutellarein alkyl derivatives as preventing neurodegenerative agents with improved lipid soluble properties

Background: Exogenous antioxidants are considered as a promising therapeutic approach to treat neurodegenerative diseases since they could prevent and/or minimize the neuronal damage by oxidation. Objective: Three series of lipophilic compounds structurally based on scutellarein (2), which is one metabolite of scutellarin (1) in vivo, have been designed and synthesized. Methods: Their antioxidant activity was evaluated by detecting the 2-thiobarbituric acid reactive substance (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids, which were present in microsomal membranes of rat hepatocytes. The lipophilicity of these compounds indicated as partition coefficient between n-octanol and buffer was investigated by ultraviolet (UV) spectrophotometer. Results: This study indicated that compound 5e which had a benzyl group substituted at the C4'-OH position showed a potent antioxidant activity and good lipophilicity. Conclusion: 5e could be an effective candidate for preventing or reducing the oxidative status associated with the neurodegenerative processes.

An improved synthesis of scutellarin-7-O-glucuronid

An eight-step synthesis of scutellarin-7-O-glucuronide via a novel preparation of the intermediate 5,6,7,4′-trimethoxyflavone from a chalcone derivative is described. The conditions of certain steps were studied and optimised to give an overall yield of 20%.