335151-04-7Relevant articles and documents
On the mechanism of a double ring-closing metathesis reaction
Wallace, Debra J.
, p. 591 - 594 (2005)
A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst. A detailed study of the steps involved in the double ring-closing metathesis reaction of 2 to 3 has been carried out. Both the selectivity and mechanism were affected by choice of catalyst.
A double ring closing metathesis reaction in the rapid, enantioselective synthesis of NK-1 receptor antagonists.
Wallace,Goodman,Kennedy,Davies,Cowden,Ashwood,Cottrell,Dolling,Reider
, p. 671 - 674 (2007/10/03)
[structure: see text]. The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing metathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.