335280-94-9

Basic information

• Product Name: (R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene
• Synonyms: (R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene
• CAS NO: 335280-94-9
• Molecular Weight: 288.343
• Mol File: 335280-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene(335280-94-9)
• EPA Substance Registry System: (R)-2-benzyloxy-3-(2,3-dihydroxypropoxy)toluene(335280-94-9)

Safety Data

• Hazardous Substances Data: 335280-94-9(Hazardous Substances Data)

Upstream product

• 57090-45-6 (2R)-3-chloro-1,2-propanediol 
• 150710-99-9 2-benzyloxy-3-methylphenol 
• 57044-25-4 (R)-oxiranemethanol 

Downstream Products

• 335280-98-3 (S)-3-(2,3-ditosyloxypropoxy)-2-hydroxytoluene 
• 335280-96-1 (S)-2-benzyloxy-3-(2,3-ditosyloxypropoxy)toluene 

Relevant articles and documents

Integrated Chemical Process: Convenient Synthesis of Enantiopure 2-Hydroxymethyl-1,4-benzodioxane Derivatives under Iterative Catalysis of CsF

One-pot processes to enantiopure 2-hydroxymethyl-1,4-benzodioxane derivatives have been established under catalysis of CsF. A sequence of O-alkylation of catechols with enantiopure 3-chloro-1,2-propanediol, tosylation of the alcohol, deprotection of the benzyl ether, and intramolecular etherification can be integrated. The O-alkylation is also feasible with enantiopure oxiranes. All reactions, except debenzylation, are catalyzed by a single catalyst, CsF. The hydrogenative deprotection of the benzyl ether with Pd-C is compatible with the CsF-catalyzed reactions. The integrated protocols give rise not only to compaction of the whole processes but also to increases in overall yields.