33538-10-2

Basic information

• Product Name: 2-(isopropyl)isonicotinonitrile
• Synonyms: 2-(isopropyl)isonicotinonitrile;2-(1-Methylethyl)-4-pyridinecarbonitrile;2-Isopropylpyridine-4-carbonitrile
• CAS NO: 33538-10-2
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.1891
• EINECS: 251-567-8
• Mol File: 33538-10-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 207.9°Cat760mmHg
• Flash Point: 85.8°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.22mmHg at 25°C
• Refractive Index: 1.514
• PKA: 2.49±0.10(Predicted)
• CAS DataBase Reference: 2-(isopropyl)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(isopropyl)isonicotinonitrile(33538-10-2)
• EPA Substance Registry System: 2-(isopropyl)isonicotinonitrile(33538-10-2)

Safety Data

• Hazardous Substances Data: 33538-10-2(Hazardous Substances Data)

Usage

General Description

2-(isopropyl)isonicotinonitrile is a chemical compound with the molecular formula C11H14N2. It is a nitrile derivative of isonicotinic acid and contains an isopropyl group. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various compounds, particularly those with potential biological activity. It is also used as a reagent in organic synthesis, particularly in the formation of heterocyclic compounds. Additionally, 2-(isopropyl)isonicotinonitrile has been studied for its potential use in the development of new drugs and medicinal applications. However, it is important to handle this compound with caution, as nitriles can be toxic and should be used in a well-ventilated environment with appropriate protective equipment.

InChI:InChI=1/C9H10N2/c1-7(2)9-5-8(6-10)3-4-11-9/h3-5,7H,1-2H3

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 75-30-9 2-iodo-propane 
• 29885-70-9 4-cyanopyridine - trifluoroacetic acid 
• 79-31-2 isobutyric Acid 
• 78-84-2 isobutyraldehyde 
• 72-18-4 L-valine 
• 644-98-4 2-isopropylpyridine 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 191535-55-4 2-isopropylisonicotinic acid 
• 172294-75-6 2-isopropylpyridine-4-carbaldehyde 

Relevant articles and documents

Silver-Catalyzed Minisci Reactions Using Selectfluor as a Mild Oxidant

A new method for silver-catalyzed Minisci reactions using Selectfluor as a mild oxidant is reported. Heteroarenes and quinones both participate in radical C-H alkylation and arylation from a variety of carboxylic and boronic acid radical precursors. Several oxidatively sensitive and highly reactive radical species are successful, providing structures that are challenging to access by other means.

Unprotected Amino Acids as Stable Radical Precursors for Heterocycle C-H Functionalization

An efficient and general method for the C-H alkylation of heteroarenes using unprotected amino acids as stable alkyl radical precursors is reported. This one-pot procedure is performed open to air under aqueous conditions and is effective for several natural and unnatural amino acids. Heterocycles of varying structure are suitably functionalized, and reactivity trends reflect the nucleophilic character of the radical species generated.

P2X4 RECEPTOR MODULATING COMPOUNDS

Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.